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Article: A case for the ancient origin of coronaviruses

TitleA case for the ancient origin of coronaviruses
Authors
Issue Date2013
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2013, v. 87 n. 12, p. 7039-7045 How to Cite?
AbstractCoronaviruses are found in a diverse array of bat and bird species, which are believed to act as natural hosts. Molecular clock dating analyses of coronaviruses suggest that the most recent common ancestor of these viruses existed around 10,000 years ago. This relatively young age is in sharp contrast to the ancient evolutionary history of their putative natural hosts, which began diversifying tens of millions of years ago. Here, we attempted to resolve this discrepancy by applying more realistic evolutionary models that have previously revealed the ancient evolutionary history of other RNA viruses. By explicitly modeling variation in the strength of natural selection over time and thereby improving the modeling of substitution saturation, we found that the time to the most recent ancestor common for all coronaviruses is likely far greater (millions of years) than the previously inferred range.
Persistent Identifierhttp://hdl.handle.net/10722/185315
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWertheim, JOen_US
dc.contributor.authorChu, KWen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorKosakovsky Pond, SLen_US
dc.contributor.authorPoon, LLMen_US
dc.date.accessioned2013-07-15T11:00:09Z-
dc.date.available2013-07-15T11:00:09Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Virology, 2013, v. 87 n. 12, p. 7039-7045en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/185315-
dc.description.abstractCoronaviruses are found in a diverse array of bat and bird species, which are believed to act as natural hosts. Molecular clock dating analyses of coronaviruses suggest that the most recent common ancestor of these viruses existed around 10,000 years ago. This relatively young age is in sharp contrast to the ancient evolutionary history of their putative natural hosts, which began diversifying tens of millions of years ago. Here, we attempted to resolve this discrepancy by applying more realistic evolutionary models that have previously revealed the ancient evolutionary history of other RNA viruses. By explicitly modeling variation in the strength of natural selection over time and thereby improving the modeling of substitution saturation, we found that the time to the most recent ancestor common for all coronaviruses is likely far greater (millions of years) than the previously inferred range.-
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_US
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]en_US
dc.titleA case for the ancient origin of coronavirusesen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=87&issue=12&spage=7039&epage=7045&date=2013&atitle=A+case+for+the+ancient+origin+of+coronavirusesen_US
dc.identifier.emailChu, KW: dkwchu@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.03273-12-
dc.identifier.pmid23596293-
dc.identifier.pmcidPMC3676139-
dc.identifier.scopuseid_2-s2.0-84878524955-
dc.identifier.hkuros216131en_US
dc.identifier.volume87en_US
dc.identifier.issue12en_US
dc.identifier.spage7039en_US
dc.identifier.epage7045en_US
dc.identifier.isiWOS:000319508600046-
dc.identifier.issnl0022-538X-

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