File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.neulet.2003.09.043
- Scopus: eid_2-s2.0-0345528176
- PMID: 14665419
- WOS: WOS:000187358900015
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation
Title | Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation |
---|---|
Authors | |
Keywords | Hyperalgesia Inflammatory pain Nociceptive response Rats Spinal dynorphin expression Strain-dependent difference |
Issue Date | 2003 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 2003, v. 353 n. 3, p. 213-216 How to Cite? |
Abstract | The experience of pain is highly variable among individuals, which may be due in part to the effects of genetic factors on the central transmission and modulation of noxious inputs. This study examined behavioral responses and the expression of preprodynorphin (PPD) mRNA at the spinal level during complete Freund's adjuvant-induced inflammation of the unilateral hind paw in male Fischer 344 (F344), Sprague-Dawley (SD), and Lewis (LEW) rats. Experiments showed that F344 rats exhibited stronger hind paw hyperalgesia and greater spinal PPD mRNA induction than SD or LEW rats. These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception. © 2003 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188554 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Qiao, JT | en_US |
dc.contributor.author | Ruda, MA | en_US |
dc.date.accessioned | 2013-09-03T04:10:15Z | - |
dc.date.available | 2013-09-03T04:10:15Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Neuroscience Letters, 2003, v. 353 n. 3, p. 213-216 | en_US |
dc.identifier.issn | 0304-3940 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188554 | - |
dc.description.abstract | The experience of pain is highly variable among individuals, which may be due in part to the effects of genetic factors on the central transmission and modulation of noxious inputs. This study examined behavioral responses and the expression of preprodynorphin (PPD) mRNA at the spinal level during complete Freund's adjuvant-induced inflammation of the unilateral hind paw in male Fischer 344 (F344), Sprague-Dawley (SD), and Lewis (LEW) rats. Experiments showed that F344 rats exhibited stronger hind paw hyperalgesia and greater spinal PPD mRNA induction than SD or LEW rats. These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception. © 2003 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_US |
dc.relation.ispartof | Neuroscience Letters | en_US |
dc.subject | Hyperalgesia | - |
dc.subject | Inflammatory pain | - |
dc.subject | Nociceptive response | - |
dc.subject | Rats | - |
dc.subject | Spinal dynorphin expression | - |
dc.subject | Strain-dependent difference | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Behavior, Animal | en_US |
dc.subject.mesh | Blotting, Northern | en_US |
dc.subject.mesh | Dynorphins - Genetics - Metabolism | en_US |
dc.subject.mesh | Freund's Adjuvant | en_US |
dc.subject.mesh | Inflammation - Chemically Induced | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pain Threshold - Physiology | en_US |
dc.subject.mesh | Peripheral Nervous System Diseases - Chemically Induced - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Protein Precursors - Genetics - Metabolism | en_US |
dc.subject.mesh | Rna, Messenger - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred F344 | en_US |
dc.subject.mesh | Rats, Inbred Lew | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Species Specificity | en_US |
dc.subject.mesh | Spinal Cord - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neulet.2003.09.043 | en_US |
dc.identifier.pmid | 14665419 | - |
dc.identifier.scopus | eid_2-s2.0-0345528176 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0345528176&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 353 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 213 | en_US |
dc.identifier.epage | 216 | en_US |
dc.identifier.isi | WOS:000187358900015 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Qiao, JT=7103301572 | en_US |
dc.identifier.scopusauthorid | Ruda, MA=7005152163 | en_US |
dc.identifier.issnl | 0304-3940 | - |