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- Publisher Website: 10.1016/j.brainres.2005.01.039
- Scopus: eid_2-s2.0-14744283685
- PMID: 15757640
- WOS: WOS:000228195700013
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Article: Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation
Title | Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation |
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Authors | |
Keywords | Complete Freund's adjuvant Hyperalgesia Neonates Preprodynorphin mRNA Rats Spinal dorsal horn |
Issue Date | 2005 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres |
Citation | Brain Research, 2005, v. 1038 n. 2, p. 238-242 How to Cite? |
Abstract | Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations. © 2005 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188560 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Liu, B | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Qiao, JT | en_US |
dc.contributor.author | Ruda, MA | en_US |
dc.date.accessioned | 2013-09-03T04:10:16Z | - |
dc.date.available | 2013-09-03T04:10:16Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Brain Research, 2005, v. 1038 n. 2, p. 238-242 | en_US |
dc.identifier.issn | 0006-8993 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188560 | - |
dc.description.abstract | Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations. © 2005 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres | en_US |
dc.relation.ispartof | Brain Research | en_US |
dc.subject | Complete Freund's adjuvant | - |
dc.subject | Hyperalgesia | - |
dc.subject | Neonates | - |
dc.subject | Preprodynorphin mRNA | - |
dc.subject | Rats | - |
dc.subject | Spinal dorsal horn | - |
dc.subject.mesh | Aging - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Animals, Newborn - Metabolism | en_US |
dc.subject.mesh | Behavior, Animal - Drug Effects | en_US |
dc.subject.mesh | Blotting, Northern | en_US |
dc.subject.mesh | Dynorphins - Biosynthesis | en_US |
dc.subject.mesh | Electrophoresis, Polyacrylamide Gel | en_US |
dc.subject.mesh | Inflammation - Metabolism | en_US |
dc.subject.mesh | Protein Precursors - Biosynthesis | en_US |
dc.subject.mesh | Rna, Messenger - Biosynthesis | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Reverse Transcriptase Polymerase Chain Reaction | en_US |
dc.subject.mesh | Spinal Cord - Metabolism | en_US |
dc.subject.mesh | Up-Regulation - Genetics | en_US |
dc.title | Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.brainres.2005.01.039 | en_US |
dc.identifier.pmid | 15757640 | en_US |
dc.identifier.scopus | eid_2-s2.0-14744283685 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-14744283685&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1038 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 238 | en_US |
dc.identifier.epage | 242 | en_US |
dc.identifier.isi | WOS:000228195700013 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Liu, B=55720712900 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Qiao, JT=7103301572 | en_US |
dc.identifier.scopusauthorid | Ruda, MA=7005152163 | en_US |
dc.identifier.issnl | 0006-8993 | - |