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- Publisher Website: 10.1016/j.brainres.2003.11.042
- Scopus: eid_2-s2.0-1642513492
- PMID: 14746931
- WOS: WOS:000189091200016
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Article: Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation
Title | Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation |
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Authors | |
Keywords | Freund's adjuvant Inflammation Persistent pain Serotonin Spinal cord Substance P |
Issue Date | 2004 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres |
Citation | Brain Research, 2004, v. 999 n. 1, p. 135-141 How to Cite? |
Abstract | The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain. © 2003 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188561 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Qiao, JT | en_US |
dc.contributor.author | Ruda, MA | en_US |
dc.date.accessioned | 2013-09-03T04:10:17Z | - |
dc.date.available | 2013-09-03T04:10:17Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Brain Research, 2004, v. 999 n. 1, p. 135-141 | en_US |
dc.identifier.issn | 0006-8993 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188561 | - |
dc.description.abstract | The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain. © 2003 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres | en_US |
dc.relation.ispartof | Brain Research | en_US |
dc.subject | Freund's adjuvant | - |
dc.subject | Inflammation | - |
dc.subject | Persistent pain | - |
dc.subject | Serotonin | - |
dc.subject | Spinal cord | - |
dc.subject | Substance P | - |
dc.subject.mesh | Aging - Metabolism - Pathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chronic Disease | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Dynorphins - Genetics - Metabolism | en_US |
dc.subject.mesh | Freund's Adjuvant | en_US |
dc.subject.mesh | Functional Laterality - Physiology | en_US |
dc.subject.mesh | Hyperalgesia - Chemically Induced - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Inflammation - Chemically Induced - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Peripheral Nervous System Diseases - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Physical Stimulation | en_US |
dc.subject.mesh | Posterior Horn Cells - Metabolism | en_US |
dc.subject.mesh | Protein Precursors - Genetics | en_US |
dc.subject.mesh | Rna, Messenger - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Up-Regulation - Physiology | en_US |
dc.title | Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.brainres.2003.11.042 | en_US |
dc.identifier.pmid | 14746931 | - |
dc.identifier.scopus | eid_2-s2.0-1642513492 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1642513492&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 999 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 135 | en_US |
dc.identifier.epage | 141 | en_US |
dc.identifier.isi | WOS:000189091200016 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Qiao, JT=7103301572 | en_US |
dc.identifier.scopusauthorid | Ruda, MA=7005152163 | en_US |
dc.identifier.issnl | 0006-8993 | - |