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- Publisher Website: 10.1016/j.neulet.2004.02.014
- Scopus: eid_2-s2.0-1842504394
- PMID: 15050718
- WOS: WOS:000220768800022
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Article: Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation
Title | Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation |
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Authors | |
Keywords | Dexamethasone Dynorphin Gene expression Hyperalgesia Pain Rat Spinal cord |
Issue Date | 2004 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 2004, v. 359 n. 1-2, p. 85-88 How to Cite? |
Abstract | Glucocorticoids (GC) play important roles in response to stressful stimuli, including pain. This study examined the effects of bilateral adrenalectomy (ADX) and dexamethasone (DEX) replacement on the hyperalgesia and spinal preprodynorphin (PPD) mRNA expression induced by injecting complete Freund's adjuvant (CFA) into rats' hind paws. The results demonstrated that CFA induced more intense hyperalgesia and up-expression of spinal PPD mRNA in ADX rats than in control rats, while both of these intensified reactions could be significantly suppressed by subcutaneous pretreatment with DEX. This leads to the conclusion that both exogenous (pharmacological) and endogenous (physiological) GC suppresses the behavioral hyperalgesia and the up-regulation of spinal PPD mRNA induced by sustained peripheral inflammation. The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia. © 2004 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188566 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Qiao, JT | en_US |
dc.contributor.author | Malsnee, K | en_US |
dc.contributor.author | Ruda, MA | en_US |
dc.date.accessioned | 2013-09-03T04:10:19Z | - |
dc.date.available | 2013-09-03T04:10:19Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Neuroscience Letters, 2004, v. 359 n. 1-2, p. 85-88 | en_US |
dc.identifier.issn | 0304-3940 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188566 | - |
dc.description.abstract | Glucocorticoids (GC) play important roles in response to stressful stimuli, including pain. This study examined the effects of bilateral adrenalectomy (ADX) and dexamethasone (DEX) replacement on the hyperalgesia and spinal preprodynorphin (PPD) mRNA expression induced by injecting complete Freund's adjuvant (CFA) into rats' hind paws. The results demonstrated that CFA induced more intense hyperalgesia and up-expression of spinal PPD mRNA in ADX rats than in control rats, while both of these intensified reactions could be significantly suppressed by subcutaneous pretreatment with DEX. This leads to the conclusion that both exogenous (pharmacological) and endogenous (physiological) GC suppresses the behavioral hyperalgesia and the up-regulation of spinal PPD mRNA induced by sustained peripheral inflammation. The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia. © 2004 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_US |
dc.relation.ispartof | Neuroscience Letters | en_US |
dc.subject | Dexamethasone | - |
dc.subject | Dynorphin | - |
dc.subject | Gene expression | - |
dc.subject | Hyperalgesia | - |
dc.subject | Pain | - |
dc.subject | Rat | - |
dc.subject | Spinal cord | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dynorphins - Antagonists & Inhibitors - Biosynthesis | en_US |
dc.subject.mesh | Freund's Adjuvant | en_US |
dc.subject.mesh | Glucocorticoids - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Hyperalgesia - Chemically Induced - Metabolism | en_US |
dc.subject.mesh | Inflammation - Chemically Induced - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Protein Precursors - Antagonists & Inhibitors - Biosynthesis | en_US |
dc.subject.mesh | Rna, Messenger - Antagonists & Inhibitors - Biosynthesis | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Spinal Cord - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Up-Regulation - Drug Effects - Physiology | en_US |
dc.title | Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neulet.2004.02.014 | en_US |
dc.identifier.pmid | 15050718 | - |
dc.identifier.scopus | eid_2-s2.0-1842504394 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1842504394&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 359 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 85 | en_US |
dc.identifier.epage | 88 | en_US |
dc.identifier.isi | WOS:000220768800022 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Qiao, JT=7103301572 | en_US |
dc.identifier.scopusauthorid | Malsnee, K=6506780864 | en_US |
dc.identifier.scopusauthorid | Ruda, MA=7005152163 | en_US |
dc.identifier.issnl | 0304-3940 | - |