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- Publisher Website: 10.1016/j.brainres.2004.05.067
- Scopus: eid_2-s2.0-4143095861
- PMID: 15312782
- WOS: WOS:000223711200002
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Article: Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
Title | Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation |
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Authors | |
Keywords | Acupuncture Analgesia Freund's adjuvant Inflammation Pain Pain modulation: anatomy and physiology Sensory systems Spinal cord |
Issue Date | 2004 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres |
Citation | Brain Research, 2004, v. 1020 n. 1-2, p. 12-17 How to Cite? |
Abstract | Our previous study showed that electroacupuncture (EA) significantly attenuated inflammatory hyperalgesia. It has also been reported that EA analgesia in uninjured animals is mediated by μ and δ opioid receptors at 2-15 Hz and by κ opioid receptor at 100 Hz. Because persistent pain changes neural response to external stimulation, we hypothesized that (1) the mechanisms of EA anti-hyperalgesia may be different under conditions of persistent pain and that (2) combining EA with a sub-effective dose of morphine could enhance EA anti-hyperalgesia. Hyperalgesia, decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats. Selective antagonists against μ (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-ThrNH2, CTOP), δ (naltrinodole, NTI) and κ (nor-binaltorphimine, BNI) opioid receptors were administered intrathecally 10 min before each of two EA treatments at acupoint Huantiao (GB30), one immediately post and the other 2 h post-CFA. Morphine was given (i.p.) 40 min before the second EA treatment. PWL was measured before and 2.5 and 5 h post-CFA. Both 10 and 100 Hz EA-produced anti-hyperalgesia were blocked spinally by μ- and δ- but not κ-receptor antagonists. EA combined with a sub-threshold dose of morphine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) compared to that produced by each component alone. These results suggest selective involvement of μ and δ, but not κ, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain. © 2004 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188596 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Wang, L | en_US |
dc.contributor.author | Liu, B | en_US |
dc.contributor.author | Wang, X | en_US |
dc.contributor.author | Ren, K | en_US |
dc.contributor.author | Berman, BM | en_US |
dc.date.accessioned | 2013-09-03T04:10:30Z | - |
dc.date.available | 2013-09-03T04:10:30Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Brain Research, 2004, v. 1020 n. 1-2, p. 12-17 | en_US |
dc.identifier.issn | 0006-8993 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188596 | - |
dc.description.abstract | Our previous study showed that electroacupuncture (EA) significantly attenuated inflammatory hyperalgesia. It has also been reported that EA analgesia in uninjured animals is mediated by μ and δ opioid receptors at 2-15 Hz and by κ opioid receptor at 100 Hz. Because persistent pain changes neural response to external stimulation, we hypothesized that (1) the mechanisms of EA anti-hyperalgesia may be different under conditions of persistent pain and that (2) combining EA with a sub-effective dose of morphine could enhance EA anti-hyperalgesia. Hyperalgesia, decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats. Selective antagonists against μ (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-ThrNH2, CTOP), δ (naltrinodole, NTI) and κ (nor-binaltorphimine, BNI) opioid receptors were administered intrathecally 10 min before each of two EA treatments at acupoint Huantiao (GB30), one immediately post and the other 2 h post-CFA. Morphine was given (i.p.) 40 min before the second EA treatment. PWL was measured before and 2.5 and 5 h post-CFA. Both 10 and 100 Hz EA-produced anti-hyperalgesia were blocked spinally by μ- and δ- but not κ-receptor antagonists. EA combined with a sub-threshold dose of morphine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) compared to that produced by each component alone. These results suggest selective involvement of μ and δ, but not κ, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain. © 2004 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres | en_US |
dc.relation.ispartof | Brain Research | en_US |
dc.subject | Acupuncture | - |
dc.subject | Analgesia | - |
dc.subject | Freund's adjuvant | - |
dc.subject | Inflammation | - |
dc.subject | Pain | - |
dc.subject | Pain modulation: anatomy and physiology | - |
dc.subject | Sensory systems | - |
dc.subject | Spinal cord | - |
dc.subject.mesh | Analgesics, Opioid - Pharmacology | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chronic Disease | en_US |
dc.subject.mesh | Combined Modality Therapy | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Electroacupuncture | en_US |
dc.subject.mesh | Hyperalgesia - Physiopathology - Therapy | en_US |
dc.subject.mesh | Inflammation - Complications - Physiopathology - Therapy | en_US |
dc.subject.mesh | Injections, Spinal | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Morphine - Pharmacology | en_US |
dc.subject.mesh | Narcotic Antagonists - Administration & Dosage | en_US |
dc.subject.mesh | Pain - Etiology - Physiopathology | en_US |
dc.subject.mesh | Pain Management | en_US |
dc.subject.mesh | Random Allocation | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Reaction Time - Drug Effects | en_US |
dc.subject.mesh | Receptors, Opioid - Classification - Metabolism | en_US |
dc.title | Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.brainres.2004.05.067 | en_US |
dc.identifier.pmid | 15312782 | en_US |
dc.identifier.scopus | eid_2-s2.0-4143095861 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4143095861&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1020 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 12 | en_US |
dc.identifier.epage | 17 | en_US |
dc.identifier.isi | WOS:000223711200002 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Wang, L=9036448600 | en_US |
dc.identifier.scopusauthorid | Liu, B=55720712900 | en_US |
dc.identifier.scopusauthorid | Wang, X=7501857339 | en_US |
dc.identifier.scopusauthorid | Ren, K=7102272533 | en_US |
dc.identifier.scopusauthorid | Berman, BM=35458606800 | en_US |
dc.identifier.issnl | 0006-8993 | - |