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Conference Paper: Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications
Title | Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications |
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Authors | |
Keywords | Active ingredients Biomedical applications Core-shell microspheres Core-shell particle Encapsulation efficiency Microfluidic method Narrow size distributions Poly(lactic-co-glycolic acid) |
Issue Date | 2013 |
Publisher | American Institute of Physics. The Journal's web site is located at http://bmf.aip.org |
Citation | The 3rd European Conference on Microfluidics (μFlu'12), Heidelberg, Germany, 3-5 December 2012. In Biomicrofluidics, 2013, v. 7 n. 4, article no. 044128, p. 1-9 How to Cite? |
Abstract | We report a facile and robust microfluidic method to fabricate polymeric core-shell microspheres as delivery vehicles for biomedical applications. The characteristics of core-shell microspheres can be precisely and easily tuned by manipulating the microfluidic double emulsion templates. The addition of a shell can significantly improve the versatility as well as functionality of these microspheres as delivery vehicles. We demonstrate that the nature of the shell material plays an important role in the properties of the core-shell delivery vehicles. The release kinetics is significantly influenced by the material of the shell and other characteristics such as the thickness. For example, by adding a poly(lactic-co-glycolic acid) (PLGA) shell to an alginate core, the encapsulation efficiency is enhanced and undesired leakage of hydrophilic actives is prevented. By contrast, adding an alginate shell to PLGA core can lead to a reduction of the initial release rate, thus extending the release period of hydrophobic actives. Microfluidic fabrication enables the generation of precisely controlled core-shell microspheres with a narrow size distribution, which enables the investigation of the relationship between the release kinetics of these microspheres and their characteristics. The approach of using core-shell particles as delivery vehicles creates new opportunities to customize the release kinetics of active ingredients. © 2013 AIP Publishing LLC. |
Description | Footnote in article: Paper submitted as part of the 3rd European Conference on Microfluidics ... 2012 |
Persistent Identifier | http://hdl.handle.net/10722/189158 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.516 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, T | en_US |
dc.contributor.author | Wu, J | en_US |
dc.contributor.author | Yeung, KWK | en_US |
dc.contributor.author | To, MKT | en_US |
dc.contributor.author | Shum, HC | en_US |
dc.contributor.author | Wang, L | en_US |
dc.date.accessioned | 2013-09-17T14:28:43Z | - |
dc.date.available | 2013-09-17T14:28:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | The 3rd European Conference on Microfluidics (μFlu'12), Heidelberg, Germany, 3-5 December 2012. In Biomicrofluidics, 2013, v. 7 n. 4, article no. 044128, p. 1-9 | - |
dc.identifier.issn | 1932-1058 | - |
dc.identifier.uri | http://hdl.handle.net/10722/189158 | - |
dc.description | Footnote in article: Paper submitted as part of the 3rd European Conference on Microfluidics ... 2012 | - |
dc.description.abstract | We report a facile and robust microfluidic method to fabricate polymeric core-shell microspheres as delivery vehicles for biomedical applications. The characteristics of core-shell microspheres can be precisely and easily tuned by manipulating the microfluidic double emulsion templates. The addition of a shell can significantly improve the versatility as well as functionality of these microspheres as delivery vehicles. We demonstrate that the nature of the shell material plays an important role in the properties of the core-shell delivery vehicles. The release kinetics is significantly influenced by the material of the shell and other characteristics such as the thickness. For example, by adding a poly(lactic-co-glycolic acid) (PLGA) shell to an alginate core, the encapsulation efficiency is enhanced and undesired leakage of hydrophilic actives is prevented. By contrast, adding an alginate shell to PLGA core can lead to a reduction of the initial release rate, thus extending the release period of hydrophobic actives. Microfluidic fabrication enables the generation of precisely controlled core-shell microspheres with a narrow size distribution, which enables the investigation of the relationship between the release kinetics of these microspheres and their characteristics. The approach of using core-shell particles as delivery vehicles creates new opportunities to customize the release kinetics of active ingredients. © 2013 AIP Publishing LLC. | - |
dc.language | eng | en_US |
dc.publisher | American Institute of Physics. The Journal's web site is located at http://bmf.aip.org | - |
dc.relation.ispartof | Biomicrofluidics | en_US |
dc.rights | Copyright 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Biomicrofluidics, 2013, v. 7 n. 4, article no. 044128, p. 1-9 and may be found at https://doi.org/10.1063/1.4819274 | - |
dc.subject | Active ingredients | - |
dc.subject | Biomedical applications | - |
dc.subject | Core-shell microspheres | - |
dc.subject | Core-shell particle | - |
dc.subject | Encapsulation efficiency | - |
dc.subject | Microfluidic method | - |
dc.subject | Narrow size distributions | - |
dc.subject | Poly(lactic-co-glycolic acid) | - |
dc.title | Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wu, J: jwuhku@hku.hk | en_US |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | en_US |
dc.identifier.email | To, MKT: mikektto@hku.hk | en_US |
dc.identifier.email | Shum, HC: ashum@hku.hk | en_US |
dc.identifier.email | Wang, L: lqwang@hku.hk | - |
dc.identifier.authority | Yeung, KWK=rp00309 | en_US |
dc.identifier.authority | To, MKT=rp00302 | en_US |
dc.identifier.authority | Shum, HC=rp01439 | en_US |
dc.identifier.authority | Wang, L=rp00184 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1063/1.4819274 | - |
dc.identifier.pmid | 24404061 | - |
dc.identifier.pmcid | PMC3772936 | - |
dc.identifier.scopus | eid_2-s2.0-84883355633 | - |
dc.identifier.hkuros | 221249 | en_US |
dc.identifier.hkuros | 223198 | - |
dc.identifier.hkuros | 240078 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | article no. 044128, p. 1 | - |
dc.identifier.epage | article no. 044128, p. 9 | - |
dc.identifier.isi | WOS:000323907600030 | - |
dc.publisher.place | United States | - |
dc.customcontrol.immutable | sml 140102 | - |
dc.identifier.issnl | 1932-1058 | - |