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Article: Prevalence of and associations with reduced exercise capacity in peritoneal dialysis patients

TitlePrevalence of and associations with reduced exercise capacity in peritoneal dialysis patients
Authors
Keywordsend-stage renal disease
Exercise capacity
Issue Date2013
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American journal of kidney diseases, 2013, v. 62 n. 5, p. 939-946 How to Cite?
AbstractBACKGROUND: Exercise capacity is reduced in patients with end-stage renal disease on maintenance home peritoneal dialysis therapy, although the potential mechanisms and clinical implications remain unclear. STUDY DESIGN: Cross-sectional study. SETTING and PARTICIPANTS: 95 ambulatory prevalent and incident peritoneal dialysis patients in a well-established renal dialysis center (mean age, 58.26 +/- 12.6 [SD] years; 63% men; mean duration of peritoneal dialysis therapy, 3.2 +/- 4.1 years). PREDICTOR: Estimated volume status using spectral bioelectrical impedance, echocardiography-derived hemodynamic parameters. OUTCOME: Exercise capacity measured as peak oxygen consumption using symptom-limiting treadmill exercise testing. RESULTS: Exercise capacity was reduced in 96% of patients and severely reduced in 65%. Extracellular to intracellular fluid volume ratio showed the strongest correlation with reduced exercise capacity (R = -0.63; P < 0.001) and was superior to age, pulmonary capillary wedge pressure (E:E' ratio), lean tissue mass index, and hemoglobin and albumin levels in predicting exercise intolerance. LIMITATIONS: Relatively small sample size and echocardiogram that was performed only at rest. CONCLUSIONS: There was a strong relationship between body extracellular to intracellular fluid volume ratio and exercise capacity in peritoneal dialysis patients. These findings provide new evidence for a connection between fluid distribution, muscle mass, and exercise capacity. Therapeutic strategies targeting fluid status and muscle mass may improve the exercise capacity of patients on peritoneal dialysis therapy.
Persistent Identifierhttp://hdl.handle.net/10722/189287
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.096
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZuo, MLen_US
dc.contributor.authorYue, WSen_US
dc.contributor.authorYip, Ten_US
dc.contributor.authorNg, Fen_US
dc.contributor.authorLam, KFen_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorLui, SLen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorLo, WK-
dc.date.accessioned2013-09-17T14:31:18Z-
dc.date.available2013-09-17T14:31:18Z-
dc.date.issued2013en_US
dc.identifier.citationAmerican journal of kidney diseases, 2013, v. 62 n. 5, p. 939-946en_US
dc.identifier.issn0272-6386-
dc.identifier.urihttp://hdl.handle.net/10722/189287-
dc.description.abstractBACKGROUND: Exercise capacity is reduced in patients with end-stage renal disease on maintenance home peritoneal dialysis therapy, although the potential mechanisms and clinical implications remain unclear. STUDY DESIGN: Cross-sectional study. SETTING and PARTICIPANTS: 95 ambulatory prevalent and incident peritoneal dialysis patients in a well-established renal dialysis center (mean age, 58.26 +/- 12.6 [SD] years; 63% men; mean duration of peritoneal dialysis therapy, 3.2 +/- 4.1 years). PREDICTOR: Estimated volume status using spectral bioelectrical impedance, echocardiography-derived hemodynamic parameters. OUTCOME: Exercise capacity measured as peak oxygen consumption using symptom-limiting treadmill exercise testing. RESULTS: Exercise capacity was reduced in 96% of patients and severely reduced in 65%. Extracellular to intracellular fluid volume ratio showed the strongest correlation with reduced exercise capacity (R = -0.63; P < 0.001) and was superior to age, pulmonary capillary wedge pressure (E:E' ratio), lean tissue mass index, and hemoglobin and albumin levels in predicting exercise intolerance. LIMITATIONS: Relatively small sample size and echocardiogram that was performed only at rest. CONCLUSIONS: There was a strong relationship between body extracellular to intracellular fluid volume ratio and exercise capacity in peritoneal dialysis patients. These findings provide new evidence for a connection between fluid distribution, muscle mass, and exercise capacity. Therapeutic strategies targeting fluid status and muscle mass may improve the exercise capacity of patients on peritoneal dialysis therapy.-
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd-
dc.relation.ispartofAmerican journal of kidney diseasesen_US
dc.subjectend-stage renal disease-
dc.subjectExercise capacity-
dc.subject.meshHemodynamics - physiology-
dc.subject.meshKidney Failure, Chronic - physiopathology - therapy-
dc.subject.meshOxygen Consumption - physiology-
dc.subject.meshPeritoneal Dialysis-
dc.subject.meshPhysical Endurance - physiology-
dc.titlePrevalence of and associations with reduced exercise capacity in peritoneal dialysis patientsen_US
dc.typeArticleen_US
dc.identifier.emailZuo, ML: zuoml@hku.hken_US
dc.identifier.emailYue, WS: wsyue@hkucc.hku.hken_US
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.emailLui, SL: sllui@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailLo, WK: wkloc@hkucc.hku.hk-
dc.identifier.authorityLam, KF=rp00718en_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.doi10.1053/j.ajkd.2013.05.016-
dc.identifier.pmid23886613-
dc.identifier.scopuseid_2-s2.0-84886723915-
dc.identifier.hkuros225198en_US
dc.identifier.hkuros235542-
dc.identifier.volume62-
dc.identifier.issue5-
dc.identifier.spage939-
dc.identifier.epage946-
dc.identifier.isiWOS:000325985600014-
dc.publisher.placeUnited States-
dc.identifier.issnl0272-6386-

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