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- Publisher Website: 10.1016/j.aca.2013.08.031
- Scopus: eid_2-s2.0-84887408490
- PMID: 24216199
- WOS: WOS:000326684000008
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Article: Solid phase microextraction fills the gap in tissue sampling protocols
Title | Solid phase microextraction fills the gap in tissue sampling protocols |
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Authors | |
Keywords | In vivo SPME Metabolomics Surgery Tissue sampling |
Issue Date | 2013 |
Citation | Analytica Chimica Acta, 2013, v. 803, p. 75-81 How to Cite? |
Abstract | Metabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the current study, technology integrating in vivo sampling, sample preparation and global extraction of metabolites - solid phase microextraction was presented and evaluated during liver and lung transplantation in pig model. Sampling approaches, including selection of the probe, transportation, storage conditions and analyte coverage were discussed. The applicability of the method for metabolomics studies was demonstrated during lung transplantation experiments. © 2013 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/192692 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 0.998 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bojko, B | en_US |
dc.contributor.author | Gorynski, K | en_US |
dc.contributor.author | Gomez-Rios, GA | en_US |
dc.contributor.author | Knaak, JM | en_US |
dc.contributor.author | Machuca, T | en_US |
dc.contributor.author | Spetzler, VN | en_US |
dc.contributor.author | Cudjoe, E | en_US |
dc.contributor.author | Hsin, M | en_US |
dc.contributor.author | Cypel, M | en_US |
dc.contributor.author | Selzner, M | en_US |
dc.contributor.author | Liu, M | en_US |
dc.contributor.author | Keshavjee, S | en_US |
dc.contributor.author | Pawliszyn, J | en_US |
dc.date.accessioned | 2013-11-20T04:55:23Z | - |
dc.date.available | 2013-11-20T04:55:23Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Analytica Chimica Acta, 2013, v. 803, p. 75-81 | en_US |
dc.identifier.issn | 0003-2670 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/192692 | - |
dc.description.abstract | Metabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the current study, technology integrating in vivo sampling, sample preparation and global extraction of metabolites - solid phase microextraction was presented and evaluated during liver and lung transplantation in pig model. Sampling approaches, including selection of the probe, transportation, storage conditions and analyte coverage were discussed. The applicability of the method for metabolomics studies was demonstrated during lung transplantation experiments. © 2013 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Analytica Chimica Acta | en_US |
dc.subject | In vivo SPME | - |
dc.subject | Metabolomics | - |
dc.subject | Surgery | - |
dc.subject | Tissue sampling | - |
dc.title | Solid phase microextraction fills the gap in tissue sampling protocols | en_US |
dc.type | Article | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.aca.2013.08.031 | en_US |
dc.identifier.pmid | 24216199 | - |
dc.identifier.scopus | eid_2-s2.0-84887408490 | en_US |
dc.identifier.hkuros | 239181 | - |
dc.identifier.isi | WOS:000326684000008 | - |
dc.identifier.issnl | 0003-2670 | - |