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- Publisher Website: 10.1016/0006-8993(82)90108-1
- Scopus: eid_2-s2.0-0020031636
- PMID: 7093657
- WOS: WOS:A1982NP07800002
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Article: Effect of nerve growth factor on regeneration of goldfish optic axons
Title | Effect of nerve growth factor on regeneration of goldfish optic axons |
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Authors | |
Keywords | goldfish retina nerve growth factor nerve regeneration NGF optic nerve trophic factors |
Issue Date | 1982 |
Citation | Brain Research, 1982, v. 238 n. 2, p. 329-339 How to Cite? |
Abstract | Axonal outgrowth following a crush of the goldfish optic nerve was enhanced if nerve growth factor (NGF) was administered by intraocular injection or by local application to the lesion site. Various forms of NGF (β, 2.5S and 7S) were effective, producing a 20-40% decrease in the time required for recovery of the startle reaction to a bright line. A corresponding increase in axonal outgrowth was revealed by histological examination of the optic nerves. The effect produced by a single intraocular injection given at the time of the lesion was not further increased by subsequent injections. Up to 14 days after the lesion, the size of the retinal ganglion cell bodies and the incidence of nucleoli detectable by light microscopy were not affected by the NGF treatment. |
Persistent Identifier | http://hdl.handle.net/10722/194891 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yip, HK | - |
dc.contributor.author | Grafstein, B | - |
dc.date.accessioned | 2014-02-17T08:41:12Z | - |
dc.date.available | 2014-02-17T08:41:12Z | - |
dc.date.issued | 1982 | - |
dc.identifier.citation | Brain Research, 1982, v. 238 n. 2, p. 329-339 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://hdl.handle.net/10722/194891 | - |
dc.description.abstract | Axonal outgrowth following a crush of the goldfish optic nerve was enhanced if nerve growth factor (NGF) was administered by intraocular injection or by local application to the lesion site. Various forms of NGF (β, 2.5S and 7S) were effective, producing a 20-40% decrease in the time required for recovery of the startle reaction to a bright line. A corresponding increase in axonal outgrowth was revealed by histological examination of the optic nerves. The effect produced by a single intraocular injection given at the time of the lesion was not further increased by subsequent injections. Up to 14 days after the lesion, the size of the retinal ganglion cell bodies and the incidence of nucleoli detectable by light microscopy were not affected by the NGF treatment. | - |
dc.language | eng | - |
dc.relation.ispartof | Brain Research | - |
dc.subject | goldfish retina | - |
dc.subject | nerve growth factor | - |
dc.subject | nerve regeneration | - |
dc.subject | NGF | - |
dc.subject | optic nerve | - |
dc.subject | trophic factors | - |
dc.title | Effect of nerve growth factor on regeneration of goldfish optic axons | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0006-8993(82)90108-1 | - |
dc.identifier.pmid | 7093657 | - |
dc.identifier.scopus | eid_2-s2.0-0020031636 | - |
dc.identifier.volume | 238 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 329 | - |
dc.identifier.epage | 339 | - |
dc.identifier.isi | WOS:A1982NP07800002 | - |
dc.identifier.issnl | 0006-8993 | - |