File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cloning and characterization of muscle-specific kinase in chicken

TitleCloning and characterization of muscle-specific kinase in chicken
Authors
Issue Date2000
Citation
Molecular and Cellular Neuroscience, 2000, v. 16 n. 5, p. 661-673 How to Cite?
AbstractMuscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the neuromuscular junction. In the rodent, prominent mRNA expression of MuSK is restricted to skeletal muscle while the expression of agrin can also be detected in brain and certain nonneuronal tissues. The recent identification of Xenopus MuSK reveals that MuSK can be detected in tissues other than skeletal muscle, such as the neural tube, eye vesicles, and spleen. I this study, we describe the cloning and characterization of the chicken ortholog of MuSK and demonstrate that the regulation of MuSK expression in muscle is conserved from avian to rodent. Abundant mRNA expression of MuSK can be detected in early embryonic chick muscle and is up-regulated after nerve injury. More importantly, we also demonstrate that, in the chicken, MuSK mRNA is expressed during development in brain and liver, suggesting possible novel functions for MuSK. Furthermore, the regulatory profile of MuSK expression in chick muscle closely parallels that observed for acetylcholine receptor, in terms of both mRNA expression and protein localization. Finally, studies with paralyzed chicken muscle as well as with cultured chick myotubes demonstrate the dependence of MuSK on both electrical activity and trophic factors.
Persistent Identifierhttp://hdl.handle.net/10722/196642
ISSN
2021 Impact Factor: 4.626
2020 SCImago Journal Rankings: 1.519
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, FCF-
dc.contributor.authorGlass, DG-
dc.contributor.authorGies, DR-
dc.contributor.authorCheung, J-
dc.contributor.authorLai, K-O-
dc.contributor.authorFu, AKY-
dc.contributor.authorYancopoulos, GD-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:30Z-
dc.date.available2014-04-24T02:10:30Z-
dc.date.issued2000-
dc.identifier.citationMolecular and Cellular Neuroscience, 2000, v. 16 n. 5, p. 661-673-
dc.identifier.issn1044-7431-
dc.identifier.urihttp://hdl.handle.net/10722/196642-
dc.description.abstractMuscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the neuromuscular junction. In the rodent, prominent mRNA expression of MuSK is restricted to skeletal muscle while the expression of agrin can also be detected in brain and certain nonneuronal tissues. The recent identification of Xenopus MuSK reveals that MuSK can be detected in tissues other than skeletal muscle, such as the neural tube, eye vesicles, and spleen. I this study, we describe the cloning and characterization of the chicken ortholog of MuSK and demonstrate that the regulation of MuSK expression in muscle is conserved from avian to rodent. Abundant mRNA expression of MuSK can be detected in early embryonic chick muscle and is up-regulated after nerve injury. More importantly, we also demonstrate that, in the chicken, MuSK mRNA is expressed during development in brain and liver, suggesting possible novel functions for MuSK. Furthermore, the regulatory profile of MuSK expression in chick muscle closely parallels that observed for acetylcholine receptor, in terms of both mRNA expression and protein localization. Finally, studies with paralyzed chicken muscle as well as with cultured chick myotubes demonstrate the dependence of MuSK on both electrical activity and trophic factors.-
dc.languageeng-
dc.relation.ispartofMolecular and Cellular Neuroscience-
dc.titleCloning and characterization of muscle-specific kinase in chicken-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/mcne.2000.0892-
dc.identifier.pmid11083926-
dc.identifier.scopuseid_2-s2.0-0034530366-
dc.identifier.volume16-
dc.identifier.issue5-
dc.identifier.spage661-
dc.identifier.epage673-
dc.identifier.isiWOS:000165611200011-
dc.identifier.issnl1044-7431-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats