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Article: Identification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.

TitleIdentification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.
Authors
Du, LZhao, GKou, ZMa, CSun, SPoon, KMLu, LWang, LDebnath, AKZhou, YJiang, S
Issue Date2013
Citation
Journal of Virology, 2013, v. 87 n. 17, p. 9939-42 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.01048-13.
AbstractA novel human Middle East respiratory syndrome coronavirus (MERS-CoV) caused outbreaks of severe acute respiratory syndrome (SARS)-like illness with a high mortality rate, raising concerns of its pandemic potential. Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377 to 662 in the S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as a MERS-CoV vaccine.
Persistent Identifierhttp://hdl.handle.net/10722/199180

 

DC FieldValueLanguage
dc.contributor.authorDu, Len_US
dc.contributor.authorZhao, Gen_US
dc.contributor.authorKou, Zen_US
dc.contributor.authorMa, Cen_US
dc.contributor.authorSun, Sen_US
dc.contributor.authorPoon, KMen_US
dc.contributor.authorLu, Len_US
dc.contributor.authorWang, Len_US
dc.contributor.authorDebnath, AKen_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorJiang, Sen_US
dc.date.accessioned2014-07-22T01:06:16Z-
dc.date.available2014-07-22T01:06:16Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Virology, 2013, v. 87 n. 17, p. 9939-42en_US
dc.identifier.urihttp://hdl.handle.net/10722/199180-
dc.description.abstractA novel human Middle East respiratory syndrome coronavirus (MERS-CoV) caused outbreaks of severe acute respiratory syndrome (SARS)-like illness with a high mortality rate, raising concerns of its pandemic potential. Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377 to 662 in the S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as a MERS-CoV vaccine.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Virologyen_US
dc.titleIdentification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development.en_US
dc.typeArticleen_US
dc.identifier.emailPoon, KM: vinpoon@hku.hken_US
dc.identifier.doi10.1128/JVI.01048-13.en_US
dc.identifier.hkuros230800en_US
dc.identifier.volume87en_US
dc.identifier.issue17en_US
dc.identifier.spage9939en_US
dc.identifier.epage42en_US

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