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Article: Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus

TitleAntibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus
Authors
Yip, MSLeung, NHLCheung, CYLi, PHLee, HHYDaëron, MPeiris, JSMBruzzone, RJaume, M
KeywordsAntibodies
Antibody-dependent enhancement
Fcγ receptor
Macrophage
Pseudotypes
SARS-CoV
Spike
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/
Citation
Virology Journal, 2014, v. 11, p. article no. 82 How to Cite?
DOI: http://dx.doi.org/10.1186/1743-422X-11-82
AbstractPublic health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recombinant, full-length SARS-CoV Spike-protein trimers, trigger infection of immune cell lines. These observations prompted us to investigate the molecular mechanisms and responses to antibody-mediated infection in human macrophages.
Persistent Identifierhttp://hdl.handle.net/10722/199800
ISSN
1743-422X
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.016
PubMed Central ID
PMC4018502
ISI Accession Number ID
WOS:000335858400001

 

DC FieldValueLanguage
dc.contributor.authorYip, MS-
dc.contributor.authorLeung, NHL-
dc.contributor.authorCheung, CY-
dc.contributor.authorLi, PH-
dc.contributor.authorLee, HHY-
dc.contributor.authorDaëron, M-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorBruzzone, R-
dc.contributor.authorJaume, M-
dc.date.accessioned2014-07-22T01:38:29Z-
dc.date.available2014-07-22T01:38:29Z-
dc.date.issued2014-
dc.identifier.citationVirology Journal, 2014, v. 11, p. article no. 82-
dc.identifier.issn1743-422X-
dc.identifier.urihttp://hdl.handle.net/10722/199800-
dc.description.abstractPublic health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recombinant, full-length SARS-CoV Spike-protein trimers, trigger infection of immune cell lines. These observations prompted us to investigate the molecular mechanisms and responses to antibody-mediated infection in human macrophages.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/-
dc.relation.ispartofVirology Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntibodies-
dc.subjectAntibody-dependent enhancement-
dc.subjectFcγ receptor-
dc.subjectMacrophage-
dc.subjectPseudotypes-
dc.subjectSARS-CoV-
dc.subjectSpike-
dc.titleAntibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus-
dc.typeArticle-
dc.identifier.emailYip, MS: simonyms@graduate.hku.hk-
dc.identifier.emailLeung, NHL: leungnan@hku.hk-
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hk-
dc.identifier.emailLi, PH: phli@hkucc.hku.hk-
dc.identifier.emailLee, HHY: horlee@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hk-
dc.identifier.emailJaume, M: breizh@hku.hk-
dc.identifier.authorityLeung, NHL=rp02637-
dc.identifier.authorityCheung, CY=rp00404-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityBruzzone, R=rp01442-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1743-422X-11-82-
dc.identifier.pmid24885320-
dc.identifier.pmcidPMC4018502-
dc.identifier.scopuseid_2-s2.0-84900834595-
dc.identifier.hkuros230784-
dc.identifier.volume11-
dc.identifier.spagearticle no. 82-
dc.identifier.epagearticle no. 82-
dc.identifier.isiWOS:000335858400001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1743-422X-

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