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Article: Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong
Title | Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong |
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Authors | |
Keywords | Hospitalization Influenza Pandemic |
Issue Date | 2014 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/ |
Citation | BMC Infectious Diseases, 2014, v. 14, article no. 32 How to Cite? |
Abstract | BACKGROUND: Reliable assessment for the severity of the 2009 H1N1 pandemic influenza is critical for evaluation of vaccination strategies for future pandemics. This study aims to estimate the age-specific hospitalization risks of the 2009 pandemic cases during the first wave in Hong Kong, by combining the findings from the serology and disease burden studies. METHODS: Excess hospitalization rates associated with the pandemic H1N1 were estimated from Poisson regression models fitted to weekly total numbers of non-accidental hospitalization from 2005 to 2010. Age-specific infection-hospitalization risks were calculated as excess hospitalization rates divided by the attack rates in the corresponding age group, which were estimated from serology studies previously conducted in Hong Kong. RESULTS: Excess hospitalization rate associated with pandemic H1N1 was highest in the 0-4 age group (881.3 per 100,000 population), followed by the 5-14, 60+, 15-29, 50-59, 30-39 and 40-49 age groups. The hospitalization risk of the infected cases (i.e. infection-hospitalization risk) was found highest in the 60+ age group and lowest in the 15-29 age group, with the estimates of 17.5% and 0.7%, respectively. CONCLUSIONS: People aged 60 or over had a relatively high infection-hospitalization risk during the first wave of the 2009 H1N1 pandemic, despite of a low attack rate in this age group. The findings support the policy of listing older people as the priority group for pandemic vaccination. |
Persistent Identifier | http://hdl.handle.net/10722/199804 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.031 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, XL | en_US |
dc.contributor.author | Wong, CM | en_US |
dc.contributor.author | Chan, KH | en_US |
dc.contributor.author | Chan, KP | en_US |
dc.contributor.author | Cao, P | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Yang, L | en_US |
dc.date.accessioned | 2014-07-22T01:38:31Z | - |
dc.date.available | 2014-07-22T01:38:31Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | BMC Infectious Diseases, 2014, v. 14, article no. 32 | en_US |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | http://hdl.handle.net/10722/199804 | - |
dc.description.abstract | BACKGROUND: Reliable assessment for the severity of the 2009 H1N1 pandemic influenza is critical for evaluation of vaccination strategies for future pandemics. This study aims to estimate the age-specific hospitalization risks of the 2009 pandemic cases during the first wave in Hong Kong, by combining the findings from the serology and disease burden studies. METHODS: Excess hospitalization rates associated with the pandemic H1N1 were estimated from Poisson regression models fitted to weekly total numbers of non-accidental hospitalization from 2005 to 2010. Age-specific infection-hospitalization risks were calculated as excess hospitalization rates divided by the attack rates in the corresponding age group, which were estimated from serology studies previously conducted in Hong Kong. RESULTS: Excess hospitalization rate associated with pandemic H1N1 was highest in the 0-4 age group (881.3 per 100,000 population), followed by the 5-14, 60+, 15-29, 50-59, 30-39 and 40-49 age groups. The hospitalization risk of the infected cases (i.e. infection-hospitalization risk) was found highest in the 60+ age group and lowest in the 15-29 age group, with the estimates of 17.5% and 0.7%, respectively. CONCLUSIONS: People aged 60 or over had a relatively high infection-hospitalization risk during the first wave of the 2009 H1N1 pandemic, despite of a low attack rate in this age group. The findings support the policy of listing older people as the priority group for pandemic vaccination. | - |
dc.language | eng | en_US |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/ | - |
dc.relation.ispartof | BMC Infectious Diseases | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Hospitalization | - |
dc.subject | Influenza | - |
dc.subject | Pandemic | - |
dc.title | Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, CM: hrmrwcm@hku.hk | en_US |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | en_US |
dc.identifier.email | Chan, KP: kpchanaa@hku.hk | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.email | Yang, L: linyang@hku.hk | en_US |
dc.identifier.authority | Wong, CM=rp00338 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/1471-2334-14-32 | en_US |
dc.identifier.pmid | 24428855 | - |
dc.identifier.pmcid | PMC3898487 | - |
dc.identifier.scopus | eid_2-s2.0-84892380564 | - |
dc.identifier.hkuros | 230979 | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.isi | WOS:000330057900001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1471-2334 | - |