File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Specific antibiotics in the treatment of periodontitis - A proposed strategy

TitleSpecific antibiotics in the treatment of periodontitis - A proposed strategy
Authors
KeywordsAntibiotics, combination/therapeutic use
Polymerase chain reaction
Periodontal diseases/microbiology
Antibiotics, antibacterial/therapeutic use
Periodontal diseases/therapy
Periodontal diseases/epidemiology
Issue Date2004
Citation
Journal of Periodontology, 2004, v. 75, n. 1, p. 169-175 How to Cite?
AbstractBackground: The purpose of the present study was to propose a strategy for the selection of antibiotics that specifically target complexes of periodontal pathogens present in patients with periodontitis. Methods: Seven hundred seventy-four (774) patients with various forms of periodontitis were included in the study. Subgingival plaque samples were taken from the deepest periodontal pockets in each quadrant using a sterile curet, and pooled. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Eikenella corrodens, Tannerella forsythensis, Prevotella intermedia, and Prevotella nigrescens were identified by polymerase chain reaction, and the prevalence of combinations of these pathogens was determined. To each pathogen complex (PC), i.e., combination of pathogens, those antibiotics were assigned that were most specific according to the published minimum inhibitory concentration (MIC90) values and the gingival crevicular fluid (GCF) concentrations achievable in vivo. Antibiotic GCF concentrations had to be at least 10 times the MIC90 values, and the narrowest spectrum was selected with respect to the assessed periodontal pathogens. Results: Nine major PCs (each ≥3% of all patients) were found in 73.4% of all patients, whereas 38 minor PCs (each <3% of all patients) were distributed in 26.6% of all patients. Ten different antibiotic regimens were found to be specific for the total of 46 PCs; i.e., metronidazole and amoxicillin in 11 PCs (55.0% of all patients), metronidazole and amoxicillin/clavulanic acid or metronidazole and ciprofloxacin in 13 PCs (18.9%), amoxicillin in 4 PCs (8.3%), doxycycline in 2 PCs (6.1%), metronidazole in 8 PCs (4.1%), amoxicillin/clavulanic acid in 3 PCs (2.9%), clindamycin in 2 PCs (1.5%), ciprofloxacin in 2 PCs (0.4%), and tetracycline in 1 PC (0.3%). Conclusion: The results of the study indicate that there are at least 46 different combinations of the assessed periodontal pathogens in subjects with periodontitis, and at least 10 different antibiotic regimens might be required to specifically target the various pathogen complexes.
Persistent Identifierhttp://hdl.handle.net/10722/199901
ISSN
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.362
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBeikler, Thomas-
dc.contributor.authorPrior, Karola-
dc.contributor.authorEhmke, Benjamin-
dc.contributor.authorFlemmig, Thomas Frank-
dc.date.accessioned2014-07-26T23:10:53Z-
dc.date.available2014-07-26T23:10:53Z-
dc.date.issued2004-
dc.identifier.citationJournal of Periodontology, 2004, v. 75, n. 1, p. 169-175-
dc.identifier.issn0022-3492-
dc.identifier.urihttp://hdl.handle.net/10722/199901-
dc.description.abstractBackground: The purpose of the present study was to propose a strategy for the selection of antibiotics that specifically target complexes of periodontal pathogens present in patients with periodontitis. Methods: Seven hundred seventy-four (774) patients with various forms of periodontitis were included in the study. Subgingival plaque samples were taken from the deepest periodontal pockets in each quadrant using a sterile curet, and pooled. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Eikenella corrodens, Tannerella forsythensis, Prevotella intermedia, and Prevotella nigrescens were identified by polymerase chain reaction, and the prevalence of combinations of these pathogens was determined. To each pathogen complex (PC), i.e., combination of pathogens, those antibiotics were assigned that were most specific according to the published minimum inhibitory concentration (MIC90) values and the gingival crevicular fluid (GCF) concentrations achievable in vivo. Antibiotic GCF concentrations had to be at least 10 times the MIC90 values, and the narrowest spectrum was selected with respect to the assessed periodontal pathogens. Results: Nine major PCs (each ≥3% of all patients) were found in 73.4% of all patients, whereas 38 minor PCs (each <3% of all patients) were distributed in 26.6% of all patients. Ten different antibiotic regimens were found to be specific for the total of 46 PCs; i.e., metronidazole and amoxicillin in 11 PCs (55.0% of all patients), metronidazole and amoxicillin/clavulanic acid or metronidazole and ciprofloxacin in 13 PCs (18.9%), amoxicillin in 4 PCs (8.3%), doxycycline in 2 PCs (6.1%), metronidazole in 8 PCs (4.1%), amoxicillin/clavulanic acid in 3 PCs (2.9%), clindamycin in 2 PCs (1.5%), ciprofloxacin in 2 PCs (0.4%), and tetracycline in 1 PC (0.3%). Conclusion: The results of the study indicate that there are at least 46 different combinations of the assessed periodontal pathogens in subjects with periodontitis, and at least 10 different antibiotic regimens might be required to specifically target the various pathogen complexes.-
dc.languageeng-
dc.relation.ispartofJournal of Periodontology-
dc.subjectAntibiotics, combination/therapeutic use-
dc.subjectPolymerase chain reaction-
dc.subjectPeriodontal diseases/microbiology-
dc.subjectAntibiotics, antibacterial/therapeutic use-
dc.subjectPeriodontal diseases/therapy-
dc.subjectPeriodontal diseases/epidemiology-
dc.titleSpecific antibiotics in the treatment of periodontitis - A proposed strategy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1902/jop.2004.75.1.169-
dc.identifier.pmid15025229-
dc.identifier.scopuseid_2-s2.0-1542360536-
dc.identifier.volume75-
dc.identifier.issue1-
dc.identifier.spage169-
dc.identifier.epage175-
dc.identifier.eissn1943-3670-
dc.identifier.isiWOS:000189110800020-
dc.identifier.issnl0022-3492-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats