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- Publisher Website: 10.1016/j.jaut.2014.01.032
- Scopus: eid_2-s2.0-84899106298
- PMID: 24491821
- WOS: WOS:000336114600014
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Article: IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut
Title | IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut |
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Authors | |
Keywords | IL-10 Regulatory B cell Mucosal inflammation IL-33 IBD Breg |
Issue Date | 2014 |
Citation | Journal of Autoimmunity, 2014, v. 50, p. 107-122 How to Cite? |
Abstract | Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10-/-) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10-/- mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. © 2014. |
Persistent Identifier | http://hdl.handle.net/10722/200152 |
ISSN | 2023 Impact Factor: 7.9 2023 SCImago Journal Rankings: 2.558 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sattler, Susanne | - |
dc.contributor.author | Ling, Guangsheng | - |
dc.contributor.author | Xu, Damo | - |
dc.contributor.author | Hussaarts, Leonie | - |
dc.contributor.author | Romaine, Andreas | - |
dc.contributor.author | Zhao, Hongzhi | - |
dc.contributor.author | Fossati-Jimack, Liliane | - |
dc.contributor.author | Malik, Talat H. | - |
dc.contributor.author | Cook, Herbert Terence | - |
dc.contributor.author | Botto, Marina B. | - |
dc.contributor.author | Lau, Yu Lung | - |
dc.contributor.author | Smits, Hermelijn H. | - |
dc.contributor.author | Liew, Fooyew | - |
dc.contributor.author | Huang, Fangping | - |
dc.date.accessioned | 2014-07-26T23:11:12Z | - |
dc.date.available | 2014-07-26T23:11:12Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Autoimmunity, 2014, v. 50, p. 107-122 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200152 | - |
dc.description.abstract | Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10-/-) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10-/- mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. © 2014. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Autoimmunity | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | IL-10 | - |
dc.subject | Regulatory B cell | - |
dc.subject | Mucosal inflammation | - |
dc.subject | IL-33 | - |
dc.subject | IBD | - |
dc.subject | Breg | - |
dc.title | IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.jaut.2014.01.032 | - |
dc.identifier.pmid | 24491821 | - |
dc.identifier.scopus | eid_2-s2.0-84899106298 | - |
dc.identifier.hkuros | 234965 | - |
dc.identifier.volume | 50 | - |
dc.identifier.spage | 107 | - |
dc.identifier.epage | 122 | - |
dc.identifier.eissn | 1095-9157 | - |
dc.identifier.isi | WOS:000336114600014 | - |
dc.identifier.issnl | 0896-8411 | - |