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Patent History
- ApplicationPC T/CN2013086954 2013-11-12
- PublicationWO 2014071892 2014-05-15
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granted patent: LAMIN A, AN ACTIVATOR OF LONGEVITY/ANTI-AGING SIRT1 PROTEIN
| Title | LAMIN A, AN ACTIVATOR OF LONGEVITY/ANTI-AGING SIRT1 PROTEIN |
|---|---|
| Priority Date | 2012-11-12 US 12/1725252P |
| Inventors | |
| Issue Date | 6-Aug-2014 |
| Citation | WO Patent WO 2014071892. World Intellectual Property Organization (WIPO), PatentScope, 2014 How to Cite? |
| Abstract | The present invention provides methods of modulating the deacetylase activity of SIRT1 by modifying the binding affinity of lamin Ato SIRT1 via interaction modifying compound. The present invention also provides methods of screening SIRT1 modulating compounds based on the interaction between lamin A and SIRT1 protein and SIRT1-activating property of lamin A. The present invention further discloses uses of SIRT1 -activating compounds to treat patients suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1 -inhibiting compounds to treat human malignancies. |
| Persistent Identifier | http://hdl.handle.net/10722/200305 |
| DC Field | Value | Language |
|---|---|---|
| dc.date.accessioned | 2014-08-06T01:39:26Z | - |
| dc.date.available | 2014-08-06T01:39:26Z | - |
| dc.date.issued | 2014-08-06 | - |
| dc.identifier.citation | WO Patent WO 2014071892. World Intellectual Property Organization (WIPO), PatentScope, 2014 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/200305 | - |
| dc.description.abstract | The present invention provides methods of modulating the deacetylase activity of SIRT1 by modifying the binding affinity of lamin Ato SIRT1 via interaction modifying compound. The present invention also provides methods of screening SIRT1 modulating compounds based on the interaction between lamin A and SIRT1 protein and SIRT1-activating property of lamin A. The present invention further discloses uses of SIRT1 -activating compounds to treat patients suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1 -inhibiting compounds to treat human malignancies. | en_US |
| dc.title | LAMIN A, AN ACTIVATOR OF LONGEVITY/ANTI-AGING SIRT1 PROTEIN | en_US |
| dc.type | Patent | en_US |
| dc.identifier.authority | ZHOU, ZHONGJUN=rp00503 | en_US |
| dc.identifier.authority | LIU, BAOHUA=rp01485 | en_US |
| dc.description.nature | published_or_final_version | - |
| dc.contributor.inventor | ZHOU, ZHONGJUN | en_US |
| dc.contributor.inventor | LIU, BAOHUA | en_US |
| patents.identifier.application | PC T/CN2013086954 | en_US |
| patents.description.assignee | UNIV HONG KONG [CN] | en_US |
| patents.description.country | World Intellectual Property Organization (WIPO) | en_US |
| patents.date.publication | 2014-05-15 | en_US |
| patents.date.application | 2013-11-12 | en_US |
| patents.date.priority | 2012-11-12 US 12/1725252P | en_US |
| patents.description.cc | wo | en_US |
| patents.identifier.publication | WO 2014071892 | en_US |
| patents.relation.family | US 2014135271 (A1) 2014-05-15 | en_US |
| patents.description.kind | A1 | en_US |
| patents.type | Patent_granted | en_US |