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Article: The role of p21-activated kinases in hepatocellular carcinoma metastasis

TitleThe role of p21-activated kinases in hepatocellular carcinoma metastasis
Authors
Tse, EYTChing, YP
KeywordsCdc42
Hepatocellular carcinoma
p21-activated kinases
Rac1
Issue Date21-Aug-2014
PublisherBioMed Central. The Journal's web site is located at http://www.jmolecularsignaling.com
Citation
Journal of Molecular Signaling, 2014, v. 9, p. 7 How to Cite?
DOI: http://dx.doi.org/10.1186/1750-2187-9-7
AbstractThe p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and regulate cytoskeletal remodeling, cell motility and survival. In this review, we aim to summarize the findings regarding the oncogenic role and the underlying mechanisms of PAKs signaling in various cancers, and in particular highlight the prime importance of PAKs in hepatocellular carcinoma (HCC) progression and metastasis. Recent studies exploring the potential therapeutic application of PAK inhibitors will also be discussed.
Persistent Identifierhttp://hdl.handle.net/10722/200452

 

DC FieldValueLanguage
dc.contributor.authorTse, EYTen_US
dc.contributor.authorChing, YPen_US
dc.date.accessioned2014-08-21T06:46:35Z-
dc.date.available2014-08-21T06:46:35Z-
dc.date.issued2014-08-21-
dc.identifier.citationJournal of Molecular Signaling, 2014, v. 9, p. 7en_US
dc.identifier.urihttp://hdl.handle.net/10722/200452-
dc.description.abstractThe p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and regulate cytoskeletal remodeling, cell motility and survival. In this review, we aim to summarize the findings regarding the oncogenic role and the underlying mechanisms of PAKs signaling in various cancers, and in particular highlight the prime importance of PAKs in hepatocellular carcinoma (HCC) progression and metastasis. Recent studies exploring the potential therapeutic application of PAK inhibitors will also be discussed.en_US
dc.languageengen_US
dc.publisherBioMed Central. The Journal's web site is located at http://www.jmolecularsignaling.comen_US
dc.relation.ispartofJournal of Molecular Signalingen_US
dc.rightsJournal of Molecular Signaling . Copyright © BioMed Central.en_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCdc42-
dc.subjectHepatocellular carcinoma-
dc.subjectp21-activated kinases-
dc.subjectRac1-
dc.titleThe role of p21-activated kinases in hepatocellular carcinoma metastasisen_US
dc.typeArticleen_US
dc.identifier.emailTse, EYT: edithtse@graduate.hku.hken_US
dc.identifier.emailChing, YP: ypching@hku.hken_US
dc.identifier.authorityChing, YP=rp00469en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1750-2187-9-7en_US
dc.identifier.scopuseid_2-s2.0-84905396145-
dc.identifier.hkuros234331en_US
dc.identifier.volume9en_US
dc.identifier.eissn1750-2187-
dc.identifier.issnl1750-2187-

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