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- Publisher Website: 10.1016/j.rvsc.2014.06.008
- Scopus: eid_2-s2.0-84925213623
- PMID: 24997556
- WOS: WOS:000345809300020
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Article: Aflatoxicosis chemoprevention by probiotic Lactobacillius and lack of effect on the major histocompatibility complex
Title | Aflatoxicosis chemoprevention by probiotic Lactobacillius and lack of effect on the major histocompatibility complex |
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Authors | |
Keywords | Gene expression Aflatoxin Chemoprevention Toxicology Probiotics Turkeys Poultry MHC BG |
Issue Date | 2014 |
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rvsc |
Citation | Research in Veterinary Science, 2014, v. 97 n. 2, p. 274-281 How to Cite? |
Abstract | Turkeys are extremely sensitive to aflatoxin B1 (AFB1) which causes decreased growth, immunosuppression and liver necrosis. The purpose of this study was to determine whether probiotic Lactobacillus, shown to be protective in animal and clinical studies, would likewise confer protection in turkeys, which were treated for 11 days with either AFB1 (AFB; 1 ppm in diet), probiotic (PB; 1 × 1011 CFU/ml; oral, daily), probiotic + AFB1 (PBAFB), or PBS control (CNTL). The AFB1 induced drop in body and liver weights were restored to normal in CNTL and PBAFB groups. Hepatotoxicity markers were not significantly reduced by probiotic treatment. Major histocompatibility complex (MHC) genes BG1 and BG4, which are differentially expressed in liver and spleens, were not significantly affected by treatments. These data indicate modest protection, but the relatively high dietary AFB1 treatment, and the extreme sensitivity of this species may reveal limits of probiotic-based protection strategies. |
Persistent Identifier | http://hdl.handle.net/10722/201543 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.617 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rawal, S | - |
dc.contributor.author | Bauer, MM | - |
dc.contributor.author | Mendoza, KM | - |
dc.contributor.author | El-Nezami, H | - |
dc.contributor.author | Hall, JR | - |
dc.contributor.author | Kim, JE | - |
dc.contributor.author | Stevens, JR | - |
dc.contributor.author | Reed, KM | - |
dc.contributor.author | Coulombe, RA | - |
dc.date.accessioned | 2014-08-21T07:30:23Z | - |
dc.date.available | 2014-08-21T07:30:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Research in Veterinary Science, 2014, v. 97 n. 2, p. 274-281 | - |
dc.identifier.issn | 0034-5288 | - |
dc.identifier.uri | http://hdl.handle.net/10722/201543 | - |
dc.description.abstract | Turkeys are extremely sensitive to aflatoxin B1 (AFB1) which causes decreased growth, immunosuppression and liver necrosis. The purpose of this study was to determine whether probiotic Lactobacillus, shown to be protective in animal and clinical studies, would likewise confer protection in turkeys, which were treated for 11 days with either AFB1 (AFB; 1 ppm in diet), probiotic (PB; 1 × 1011 CFU/ml; oral, daily), probiotic + AFB1 (PBAFB), or PBS control (CNTL). The AFB1 induced drop in body and liver weights were restored to normal in CNTL and PBAFB groups. Hepatotoxicity markers were not significantly reduced by probiotic treatment. Major histocompatibility complex (MHC) genes BG1 and BG4, which are differentially expressed in liver and spleens, were not significantly affected by treatments. These data indicate modest protection, but the relatively high dietary AFB1 treatment, and the extreme sensitivity of this species may reveal limits of probiotic-based protection strategies. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rvsc | - |
dc.relation.ispartof | Research in Veterinary Science | - |
dc.subject | Gene expression | - |
dc.subject | Aflatoxin | - |
dc.subject | Chemoprevention | - |
dc.subject | Toxicology | - |
dc.subject | Probiotics | - |
dc.subject | Turkeys | - |
dc.subject | Poultry | - |
dc.subject | MHC | - |
dc.subject | BG | - |
dc.title | Aflatoxicosis chemoprevention by probiotic Lactobacillius and lack of effect on the major histocompatibility complex | - |
dc.type | Article | - |
dc.identifier.email | El-Nezami, H: elnezami@hkucc.hku.hk | - |
dc.identifier.authority | El-Nezami, H=rp00694 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.rvsc.2014.06.008 | - |
dc.identifier.pmid | 24997556 | - |
dc.identifier.scopus | eid_2-s2.0-84925213623 | - |
dc.identifier.hkuros | 232319 | - |
dc.identifier.volume | 97 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 274 | - |
dc.identifier.epage | 281 | - |
dc.identifier.isi | WOS:000345809300020 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0034-5288 | - |