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Article: Meta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.

TitleMeta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.
Authors
Kwan, SHHsu, YHCheung, CLDupuis, JSaint-Pierre, AEriksson, JHandelman, SKAragaki, AKarasik, DPramstaller, PPKooperberg, CLacroix, AZLarson, MGLau, KSLorentzon, MPichler, ISham, PCTaliun, DVandenput, LKiel, DPHicks, AAJackson, RDOhlsson, CBenjamin, EJKung, AWC
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, , v. 23 n. 24, p. 6684-6693 How to Cite?
DOI: http://dx.doi.org/10.1093/hmg/ddu386
AbstractOsteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.
Persistent Identifierhttp://hdl.handle.net/10722/203062
ISSN
0964-6906
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.602
PubMed Central ID
PMC4240210
ISI Accession Number ID
WOS:000347921900023

 

DC FieldValueLanguage
dc.contributor.authorKwan, SH-
dc.contributor.authorHsu, YH-
dc.contributor.authorCheung, CL-
dc.contributor.authorDupuis, J-
dc.contributor.authorSaint-Pierre, A-
dc.contributor.authorEriksson, J-
dc.contributor.authorHandelman, SK-
dc.contributor.authorAragaki, A-
dc.contributor.authorKarasik, D-
dc.contributor.authorPramstaller, PP-
dc.contributor.authorKooperberg, C-
dc.contributor.authorLacroix, AZ-
dc.contributor.authorLarson, MG-
dc.contributor.authorLau, KS-
dc.contributor.authorLorentzon, M-
dc.contributor.authorPichler, I-
dc.contributor.authorSham, PC-
dc.contributor.authorTaliun, D-
dc.contributor.authorVandenput, L-
dc.contributor.authorKiel, DP-
dc.contributor.authorHicks, AA-
dc.contributor.authorJackson, RD-
dc.contributor.authorOhlsson, C-
dc.contributor.authorBenjamin, EJ-
dc.contributor.authorKung, AWC-
dc.date.accessioned2014-09-19T11:29:24Z-
dc.date.available2014-09-19T11:29:24Z-
dc.date.issued2015-
dc.identifier.citationHuman Molecular Genetics, , v. 23 n. 24, p. 6684-6693-
dc.identifier.issn0964-6906-
dc.identifier.urihttp://hdl.handle.net/10722/203062-
dc.description.abstractOsteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/-
dc.relation.ispartofHuman Molecular Genetics-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleMeta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels.-
dc.typeArticle-
dc.identifier.emailKwan, SH: shkwan@hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.emailLau, KS: kslau@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailKung, AWC: awckung@hku.hk-
dc.identifier.authorityCheung, CL=rp01749-
dc.identifier.authoritySham, PC=rp00459-
dc.identifier.authorityKung, AWC=rp00368-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/hmg/ddu386-
dc.identifier.pmid25080503-
dc.identifier.pmcidPMC4240210-
dc.identifier.scopuseid_2-s2.0-84936776293-
dc.identifier.hkuros235556-
dc.identifier.volume23-
dc.identifier.issue24-
dc.identifier.spage6684-
dc.identifier.epage6693-
dc.identifier.isiWOS:000347921900023-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0964-6906-

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