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- Publisher Website: 10.1634/theoncologist.2012-0131
- Scopus: eid_2-s2.0-84906976007
- PMID: 25117068
- WOS: WOS:000341412300007
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Article: Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy
Title | Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy |
---|---|
Authors | |
Keywords | Advanced pancreatic cancer Biological therapy Gemcitabine Targeted therapy |
Issue Date | 2014 |
Citation | Oncologist, 2014 How to Cite? |
Abstract | The progress in the development of systemic treatment for advanced pancreatic cancer (APC) has been slow. The main stream treatment remains using chemotherapy including gemcitabine, FOLFIRINOX, and nab-paclitaxel. Erlotinib is the only approved biological therapy with marginal benefit. Studies of agents targeting epidermal growth factor receptor, angiogenesis, and RAS signaling have not been satisfying, and the usefulness of targeted therapy in APC is uncertain. Understanding in molecular processes and tumor biology has opened the door for new treatment strategies such as targeting insulin-like growth factor 1 receptor, transforming growth factor β, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Notch pathway. New directions also include the upcoming immunotherapy and many novel agents that act on the microenvironment. The practice of personalized medicine using predictive biomarkers and pharmacogenomics signatures may also enhance the effectiveness of existing treatment. Future treatment approaches may involve comprehensive genomic assessment of tumor and integrated combinations of multiple agents to overcome treatment resistance. ©AlphaMed Press 2014. |
Persistent Identifier | http://hdl.handle.net/10722/203082 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.991 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chiu, JWY | en_US |
dc.contributor.author | Wong, HYH | en_US |
dc.contributor.author | Leung, RCY | en_US |
dc.contributor.author | Pang, RWC | en_US |
dc.contributor.author | Cheung, TT | en_US |
dc.contributor.author | Fan, ST | en_US |
dc.contributor.author | Poon, RTP | en_US |
dc.contributor.author | Yau, TCC | en_US |
dc.date.accessioned | 2014-09-19T11:29:48Z | - |
dc.date.available | 2014-09-19T11:29:48Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Oncologist, 2014 | en_US |
dc.identifier.issn | 1083-7159 | - |
dc.identifier.uri | http://hdl.handle.net/10722/203082 | - |
dc.description.abstract | The progress in the development of systemic treatment for advanced pancreatic cancer (APC) has been slow. The main stream treatment remains using chemotherapy including gemcitabine, FOLFIRINOX, and nab-paclitaxel. Erlotinib is the only approved biological therapy with marginal benefit. Studies of agents targeting epidermal growth factor receptor, angiogenesis, and RAS signaling have not been satisfying, and the usefulness of targeted therapy in APC is uncertain. Understanding in molecular processes and tumor biology has opened the door for new treatment strategies such as targeting insulin-like growth factor 1 receptor, transforming growth factor β, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Notch pathway. New directions also include the upcoming immunotherapy and many novel agents that act on the microenvironment. The practice of personalized medicine using predictive biomarkers and pharmacogenomics signatures may also enhance the effectiveness of existing treatment. Future treatment approaches may involve comprehensive genomic assessment of tumor and integrated combinations of multiple agents to overcome treatment resistance. ©AlphaMed Press 2014. | - |
dc.language | eng | en_US |
dc.relation.ispartof | Oncologist | en_US |
dc.subject | Advanced pancreatic cancer | - |
dc.subject | Biological therapy | - |
dc.subject | Gemcitabine | - |
dc.subject | Targeted therapy | - |
dc.title | Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chiu, JWY: jwychiu@hku.hk | en_US |
dc.identifier.email | Wong, HYH: hildahy@hku.hk | en_US |
dc.identifier.email | Pang, RWC: robertap@hku.hk | en_US |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_US |
dc.identifier.email | Poon, RTP: poontp@hku.hk | en_US |
dc.identifier.email | Yau, TCC: tyaucc@hku.hk | en_US |
dc.identifier.authority | Chiu, JWY=rp01917 | en_US |
dc.identifier.authority | Pang, RWC=rp00274 | en_US |
dc.identifier.authority | Fan, ST=rp00355 | en_US |
dc.identifier.authority | Poon, RTP=rp00446 | en_US |
dc.identifier.authority | Yau, TCC=rp01466 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1634/theoncologist.2012-0131 | - |
dc.identifier.pmid | 25117068 | - |
dc.identifier.scopus | eid_2-s2.0-84906976007 | - |
dc.identifier.hkuros | 236944 | en_US |
dc.identifier.isi | WOS:000341412300007 | - |
dc.identifier.issnl | 1083-7159 | - |