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Conference Paper: Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice
| Title | Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice |
|---|---|
| Authors | |
| Issue Date | 2013 |
| Publisher | ET-13 International Conference. |
| Citation | The 13th International Conference on Endothelin (ET-13), Tokyo, Japan, 8-11 September 2013. In ET-13 Program & Abstracts, 2013, p. 53, abstract O-5 How to Cite? |
| Abstract | Circulating levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. The renal artery is important in controlling intrarenal blood # ow and is highly sensitive to ET-1. Whether or not ET-1 affects renal artery tone in obesity is unknown. To investigate the role of endogenous ET-1, a mouse model with tie-1 promoter-driven endothelium-restricted heterozygous overexpression of preproendothelin-1 was used (TET+/-). Obesity was induced in TET+/- and WT littermates by feeding a high fat diet ... |
| Description | Session 3: Renal Diseases: O-5 |
| Persistent Identifier | http://hdl.handle.net/10722/203720 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Baretella, OM | en_US |
| dc.contributor.author | Chung, SK | en_US |
| dc.contributor.author | Xu, A | en_US |
| dc.contributor.author | Vanhoutte, PM | en_US |
| dc.date.accessioned | 2014-09-19T16:11:29Z | - |
| dc.date.available | 2014-09-19T16:11:29Z | - |
| dc.date.issued | 2013 | en_US |
| dc.identifier.citation | The 13th International Conference on Endothelin (ET-13), Tokyo, Japan, 8-11 September 2013. In ET-13 Program & Abstracts, 2013, p. 53, abstract O-5 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/203720 | - |
| dc.description | Session 3: Renal Diseases: O-5 | - |
| dc.description.abstract | Circulating levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. The renal artery is important in controlling intrarenal blood # ow and is highly sensitive to ET-1. Whether or not ET-1 affects renal artery tone in obesity is unknown. To investigate the role of endogenous ET-1, a mouse model with tie-1 promoter-driven endothelium-restricted heterozygous overexpression of preproendothelin-1 was used (TET+/-). Obesity was induced in TET+/- and WT littermates by feeding a high fat diet ... | - |
| dc.language | eng | en_US |
| dc.publisher | ET-13 International Conference. | - |
| dc.relation.ispartof | International Conference on Endothelin, ET-13 | en_US |
| dc.title | Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Chung, SK: skchung@hkucc.hku.hk | en_US |
| dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_US |
| dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_US |
| dc.identifier.authority | Chung, SK=rp00381 | en_US |
| dc.identifier.authority | Xu, A=rp00485 | en_US |
| dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 238784 | en_US |
| dc.identifier.spage | 53 | - |
| dc.identifier.epage | 53 | - |
| dc.publisher.place | Japan | - |