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Conference Paper: Comparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritis
Title | Comparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritis |
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Authors | |
Issue Date | 2013 |
Citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.8 How to Cite? |
Abstract | Introduction: It was recently reported that inflammation is involved in the pathogenesis of osteoarthritis (OA). Fattyacid-binding
protein 4 (FABP4) and adiponectin are both adipocyte-derived cytokines closely related with inflammation
pathways. The FABP4 exhibits a pro-inflammatory property while adiponectin shows anti-inflammatory effect. The study
aimed to assess the expression of FABP4 and adiponectin in paired blood and synovial fluid from OA patients, and to
examine whether the infrapatellar fat pad (IPFP) from OA subjects would release FABP4 and adiponectin similar to that of
donor-matched subcutaneous adipose tissue (ScAT).
Materials and Methods: Plasma, synovial fluid, ScAT, and IPFP of 20 OA patients (4 males and 16 females) were collected
during total knee arthroplasty. Levels of FABP4 and adiponectin were measured in plasma, synovial fluid, and fat
conditioned media using ELISA (AIS, HKU).
Results: Levels of FABP4 were significantly higher in IPFP media than ScAT (p = 0.015), while the same were significantly
higher in synovial fluid than in plasma (p < 0.001). There were no significant differences of adiponectin levels between
IPFP and ScAT media (p = 0.737). Plasma levels of adiponectin were significantly higher than synovial fluid (p < 0.001).
Discussion and Conclusion: The OA patients exhibit an inflammatory state in local environment (IPFP and synovial fluid)
compared with systemic environment (ScAT and plasma). The IPFP may play a key role in OA inflammation and may be
an important resource of inflammatory mediators in synovial fluid. |
Description | Conference Theme: Defying the Aging Spine: Our Mission Continues Concurrent Free Papers 2 - Basic Science/General Orthopaedics: no. 2.8 |
Persistent Identifier | http://hdl.handle.net/10722/203751 |
DC Field | Value | Language |
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dc.contributor.author | Li, T | en_US |
dc.contributor.author | Yan, CH | en_US |
dc.contributor.author | Xu, AM | en_US |
dc.contributor.author | Song, YQ | en_US |
dc.contributor.author | Chiu, KY | en_US |
dc.date.accessioned | 2014-09-19T16:40:08Z | - |
dc.date.available | 2014-09-19T16:40:08Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.8 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/203751 | - |
dc.description | Conference Theme: Defying the Aging Spine: Our Mission Continues | - |
dc.description | Concurrent Free Papers 2 - Basic Science/General Orthopaedics: no. 2.8 | - |
dc.description.abstract | Introduction: It was recently reported that inflammation is involved in the pathogenesis of osteoarthritis (OA). Fattyacid-binding protein 4 (FABP4) and adiponectin are both adipocyte-derived cytokines closely related with inflammation pathways. The FABP4 exhibits a pro-inflammatory property while adiponectin shows anti-inflammatory effect. The study aimed to assess the expression of FABP4 and adiponectin in paired blood and synovial fluid from OA patients, and to examine whether the infrapatellar fat pad (IPFP) from OA subjects would release FABP4 and adiponectin similar to that of donor-matched subcutaneous adipose tissue (ScAT). Materials and Methods: Plasma, synovial fluid, ScAT, and IPFP of 20 OA patients (4 males and 16 females) were collected during total knee arthroplasty. Levels of FABP4 and adiponectin were measured in plasma, synovial fluid, and fat conditioned media using ELISA (AIS, HKU). Results: Levels of FABP4 were significantly higher in IPFP media than ScAT (p = 0.015), while the same were significantly higher in synovial fluid than in plasma (p < 0.001). There were no significant differences of adiponectin levels between IPFP and ScAT media (p = 0.737). Plasma levels of adiponectin were significantly higher than synovial fluid (p < 0.001). Discussion and Conclusion: The OA patients exhibit an inflammatory state in local environment (IPFP and synovial fluid) compared with systemic environment (ScAT and plasma). The IPFP may play a key role in OA inflammation and may be an important resource of inflammatory mediators in synovial fluid. | - |
dc.language | eng | en_US |
dc.relation.ispartof | Annual Congress of the Hong Kong Orthopaedic Association, HKOA 2013 | en_US |
dc.relation.ispartof | 香港骨科醫學會第三十三屇週年會議 | - |
dc.title | Comparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritis | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Yan, CH: yanchoi@hku.hk | en_US |
dc.identifier.email | Xu, AM: amxu@hkucc.hku.hk | en_US |
dc.identifier.email | Song, YQ: songy@hku.hk | en_US |
dc.identifier.email | Chiu, KY: pkychiu@hkucc.hku.hk | en_US |
dc.identifier.authority | Yan, CH=rp00303 | en_US |
dc.identifier.authority | Xu, AM=rp00485 | en_US |
dc.identifier.authority | Song, YQ=rp00488 | en_US |
dc.identifier.authority | Chiu, KY=rp00379 | en_US |
dc.description.nature | postprint | - |
dc.identifier.hkuros | 235760 | en_US |
dc.identifier.hkuros | 240259 | - |
dc.identifier.spage | 21, abstract no. 2.8 | en_US |
dc.identifier.epage | 21, abstract no. 2.8 | en_US |