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Conference Paper: Microstructural transition and mechanical incompetence of trabecular bone around subchondral cyst in knee osteoarthritis
Title | Microstructural transition and mechanical incompetence of trabecular bone around subchondral cyst in knee osteoarthritis |
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Authors | |
Issue Date | 2013 |
Publisher | Hong Kong Academy of Medicine Press. |
Citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, China, 23-24 November 2013. In Conference Abstracts, 2013, p. 39, abstract no. 4.11 How to Cite? |
Abstract | Introduction: Subchondral bone cysts (SBCs) were associated with greater loss of articular cartilage and increased
risk of joint replacement. This study aimed to characterise subchondral bone disturbance with SBC formation in knee
osteoarthritis (OA).
Materials and Methods: Tibial specimens were collected during surgeries for a total of 70 patients (age range, 52-86 years)
with late-stage knee OA. The specimens were then divided into the SBC+ and SBC- groups according to the presence or
absence of SBCs under microcomputed tomographic evaluations. They were processed for the compressive mechanical
testing and nanoindentation sequentially. Comparisons of microstructural and mechanical properties of trabecular bone
were performed between 2 groups using Student’s t test.
Results: The SBCs were present in the majority of tibial specimens (55/70, 78.5%). Their diameter ranged from 1.5 to
14 mm. A greater increase in mean (± standard deviation) trabecular bone volume fraction (BV/TV) was found in OA
specimens with SBC+ group (24 ± 9%) compared with SBC- group (18 ± 5%, p = 0.035). It was prominent when the SBC was
< 5 mm. The mean compressive modulus of trabecular bone of SBC+ group (47 ± 23 MPa) did not statistically differ from
SBC- group (53 ± 33 MPa, p = 0.646) although the former presented higher BV/TV. The mean nano-stiffness of trabeculae
in SBC+ group (7.73 ± 1.29 GPa) was significantly lower than SBC-group (12.03 ± 1.98 MPa, p < 0.001).
Discussion and Conclusion: The presence of SBC could be an indicator for the poor quality of subchondral bone in the
pathophysiology of knee OA. |
Description | Conference Theme: Defying the Aging Spine Concurrent Free Papers 4: Hips and Knees 1 |
Persistent Identifier | http://hdl.handle.net/10722/204332 |
DC Field | Value | Language |
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dc.contributor.author | Wen, C | en_US |
dc.contributor.author | Yan, CH | en_US |
dc.contributor.author | Lu, WW | en_US |
dc.contributor.author | Chiu, PKY | en_US |
dc.date.accessioned | 2014-09-19T22:41:15Z | - |
dc.date.available | 2014-09-19T22:41:15Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, China, 23-24 November 2013. In Conference Abstracts, 2013, p. 39, abstract no. 4.11 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/204332 | - |
dc.description | Conference Theme: Defying the Aging Spine | - |
dc.description | Concurrent Free Papers 4: Hips and Knees 1 | - |
dc.description.abstract | Introduction: Subchondral bone cysts (SBCs) were associated with greater loss of articular cartilage and increased risk of joint replacement. This study aimed to characterise subchondral bone disturbance with SBC formation in knee osteoarthritis (OA). Materials and Methods: Tibial specimens were collected during surgeries for a total of 70 patients (age range, 52-86 years) with late-stage knee OA. The specimens were then divided into the SBC+ and SBC- groups according to the presence or absence of SBCs under microcomputed tomographic evaluations. They were processed for the compressive mechanical testing and nanoindentation sequentially. Comparisons of microstructural and mechanical properties of trabecular bone were performed between 2 groups using Student’s t test. Results: The SBCs were present in the majority of tibial specimens (55/70, 78.5%). Their diameter ranged from 1.5 to 14 mm. A greater increase in mean (± standard deviation) trabecular bone volume fraction (BV/TV) was found in OA specimens with SBC+ group (24 ± 9%) compared with SBC- group (18 ± 5%, p = 0.035). It was prominent when the SBC was < 5 mm. The mean compressive modulus of trabecular bone of SBC+ group (47 ± 23 MPa) did not statistically differ from SBC- group (53 ± 33 MPa, p = 0.646) although the former presented higher BV/TV. The mean nano-stiffness of trabeculae in SBC+ group (7.73 ± 1.29 GPa) was significantly lower than SBC-group (12.03 ± 1.98 MPa, p < 0.001). Discussion and Conclusion: The presence of SBC could be an indicator for the poor quality of subchondral bone in the pathophysiology of knee OA. | - |
dc.language | eng | en_US |
dc.publisher | Hong Kong Academy of Medicine Press. | - |
dc.relation.ispartof | Annual Congress of the Hong Kong Orthopaedic Association, HKOA 2013 | en_US |
dc.title | Microstructural transition and mechanical incompetence of trabecular bone around subchondral cyst in knee osteoarthritis | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wen, C: paulwen@hku.hk | en_US |
dc.identifier.email | Yan, CH: yanchoi@hku.hk | en_US |
dc.identifier.email | Lu, WW: wwlu@hku.hk | en_US |
dc.identifier.email | Chiu, PKY: pkychiu@hkucc.hku.hk | en_US |
dc.identifier.authority | Yan, CH=rp00303 | en_US |
dc.identifier.authority | Lu, WW=rp00411 | en_US |
dc.identifier.authority | Chiu, PKY=rp00379 | en_US |
dc.identifier.hkuros | 235775 | en_US |
dc.identifier.hkuros | 240334 | - |
dc.identifier.spage | 39, abstract no. 4.11 | en_US |
dc.identifier.epage | 39, abstract no. 4.11 | en_US |
dc.publisher.place | Hong Kong | - |