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Article: Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis
Title | Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis |
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Authors | |
Keywords | Bronchoscopy Hilar lymphadenopathy Mediastinum Sarcoidosis Transbronchial needle aspiration Ultrasound |
Issue Date | 2007 |
Publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com |
Citation | The European Respiratory Journal, 2007, v. 29 n. 6, p. 1182-1186 How to Cite? |
Abstract | A diagnosis of sarcoidosis should be substantiated by pathological means in order to thoroughly exclude other diseases. The role of real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis has not been reported. The purpose of the present study is to evaluate the diagnostic yield of EBUS-TBNA in demonstrating the pathological features of sarcoidosis. In total, 65 patients with suspected sarcoidosis, with enlarged hilar or mediastinal lymph nodes on computed tomography, were included in the study. Patients with a suspected or known malignancy or previously established diagnosis of sarcoidosis were excluded. Convex probe endobronchial ultrasonography integrated with a separate working channel was used for EBUS-TBNA. Surgical methods were performed in those in whom no granulomas were detected by EBUS-TBNA. Patients were followed up clinically. EBUS-TBNA was performed on a total of 77 lymph node stations in 65 patients. A final diagnosis of sarcoidosis was made for 61 (93.8%) of the patients. The remaining four patients were diagnosed as having Wegener's granulomatosis (n=1) or indefinite (n=3). In patients with a final diagnosis of sarcoidosis, EBUS-TBNA demonstrated noncaseating epithelioid cell granulomas in 56 (91.8%) of the patients. No complications were reported. Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis. |
Persistent Identifier | http://hdl.handle.net/10722/205680 |
ISSN | 2023 Impact Factor: 16.6 2023 SCImago Journal Rankings: 3.810 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, M | - |
dc.contributor.author | Yasufuku, K | - |
dc.contributor.author | Nakajima, T | - |
dc.contributor.author | Herth, FJF | - |
dc.contributor.author | Sekine, Y | - |
dc.contributor.author | Shibuya, K | - |
dc.contributor.author | Iizasa, T | - |
dc.contributor.author | Hiroshima, K | - |
dc.contributor.author | Lam, WK | - |
dc.contributor.author | Fujisawa, T | - |
dc.date.accessioned | 2014-09-30T08:45:40Z | - |
dc.date.available | 2014-09-30T08:45:40Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | The European Respiratory Journal, 2007, v. 29 n. 6, p. 1182-1186 | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | http://hdl.handle.net/10722/205680 | - |
dc.description.abstract | A diagnosis of sarcoidosis should be substantiated by pathological means in order to thoroughly exclude other diseases. The role of real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis has not been reported. The purpose of the present study is to evaluate the diagnostic yield of EBUS-TBNA in demonstrating the pathological features of sarcoidosis. In total, 65 patients with suspected sarcoidosis, with enlarged hilar or mediastinal lymph nodes on computed tomography, were included in the study. Patients with a suspected or known malignancy or previously established diagnosis of sarcoidosis were excluded. Convex probe endobronchial ultrasonography integrated with a separate working channel was used for EBUS-TBNA. Surgical methods were performed in those in whom no granulomas were detected by EBUS-TBNA. Patients were followed up clinically. EBUS-TBNA was performed on a total of 77 lymph node stations in 65 patients. A final diagnosis of sarcoidosis was made for 61 (93.8%) of the patients. The remaining four patients were diagnosed as having Wegener's granulomatosis (n=1) or indefinite (n=3). In patients with a final diagnosis of sarcoidosis, EBUS-TBNA demonstrated noncaseating epithelioid cell granulomas in 56 (91.8%) of the patients. No complications were reported. Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis. | - |
dc.language | eng | - |
dc.publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com | - |
dc.relation.ispartof | The European Respiratory Journal | - |
dc.subject | Bronchoscopy | - |
dc.subject | Hilar lymphadenopathy | - |
dc.subject | Mediastinum | - |
dc.subject | Sarcoidosis | - |
dc.subject | Transbronchial needle aspiration | - |
dc.subject | Ultrasound | - |
dc.subject.mesh | Biopsy, Fine-Needle - methods | - |
dc.subject.mesh | Bronchi - ultrasonography | - |
dc.subject.mesh | Lymph Nodes - pathology | - |
dc.subject.mesh | Lymphatic Diseases - pathology | - |
dc.subject.mesh | Sarcoidosis - diagnosis - ultrasonography | - |
dc.title | Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lam, WK: lamwk@hku.hk | - |
dc.identifier.email | Fujisawa, T: fujisawat@faculty.chiba-u.jp | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1183/09031936.00028706 | - |
dc.identifier.pmid | 17331972 | - |
dc.identifier.scopus | eid_2-s2.0-34250214937 | - |
dc.identifier.hkuros | 134673 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1182 | - |
dc.identifier.epage | 1186 | - |
dc.identifier.isi | WOS:000247280500016 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 0903-1936 | - |