File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/eip.12109
- Scopus: eid_2-s2.0-84904756814
- WOS: WOS:000339799400002
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions
Title | Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions |
---|---|
Authors | |
Keywords | Cognitive impairment Exercise Schizophrenia Glucose supplement |
Issue Date | 2014 |
Citation | Early Intervention in Psychiatry, 2014, v. 8, n. 3, p. 209-220 How to Cite? |
Abstract | Aims: Metabolic dysregulation may disrupt the complex neuroprotective mechanisms essential for brain health. Recent studies have pointed out the possible aetiological role of metabolic dysregulation in the onset of schizophrenia and the associated cognitive impairment. In this paper, we aimed to generate a theoretical model of how a combination of physical exercise and dietary glucose supplement may help to alleviate cognitive impairment in schizophrenia. Methods: Literature on metabolic dysregulation, especially insulin resistance, in relation to the onset of schizophrenia and the associated cognitive impairment is reviewed. The cognitive enhancement effects of physical exercise and dietary glucose supplement are then summarised. Finally, we propose a theoretical model based on the concerted effects of physical exercise and glucose supplement. Results: In general, the joint action of physical exercise and dietary glucose supplement could up-regulate glucose and insulin transport into the brain, as well as augmenting the release of insulin growth factor-1 and brain-derived neurotrophic factor. Physical exercise and glucose supplement could enhance energy supply and neuroplasticity in brain, subsequently leading to potential cognitive enhancement in schizophrenia. However, glucose supplement is not suitable for patients with abnormal metabolic profile. Conclusions: The combination of physical exercise and glucose supplement has potential therapeutic values in treating cognitive impairment in schizophrenia. Further research is necessary to investigate the optimal patterns of exercise and doses of glucose for treating cognitive impairment in schizophrenia. © 2013 Wiley Publishing Asia Pty Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/207095 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.976 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Yuetkeung | - |
dc.contributor.author | Hui, Christylai | - |
dc.contributor.author | Lee, Edwin | - |
dc.contributor.author | Chang, Wing Chung | - |
dc.contributor.author | Chan, Sherry Kit Wa | - |
dc.contributor.author | Leung, Chungming | - |
dc.contributor.author | Chen, Eric Y H | - |
dc.date.accessioned | 2014-12-09T04:31:23Z | - |
dc.date.available | 2014-12-09T04:31:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Early Intervention in Psychiatry, 2014, v. 8, n. 3, p. 209-220 | - |
dc.identifier.issn | 1751-7885 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207095 | - |
dc.description.abstract | Aims: Metabolic dysregulation may disrupt the complex neuroprotective mechanisms essential for brain health. Recent studies have pointed out the possible aetiological role of metabolic dysregulation in the onset of schizophrenia and the associated cognitive impairment. In this paper, we aimed to generate a theoretical model of how a combination of physical exercise and dietary glucose supplement may help to alleviate cognitive impairment in schizophrenia. Methods: Literature on metabolic dysregulation, especially insulin resistance, in relation to the onset of schizophrenia and the associated cognitive impairment is reviewed. The cognitive enhancement effects of physical exercise and dietary glucose supplement are then summarised. Finally, we propose a theoretical model based on the concerted effects of physical exercise and glucose supplement. Results: In general, the joint action of physical exercise and dietary glucose supplement could up-regulate glucose and insulin transport into the brain, as well as augmenting the release of insulin growth factor-1 and brain-derived neurotrophic factor. Physical exercise and glucose supplement could enhance energy supply and neuroplasticity in brain, subsequently leading to potential cognitive enhancement in schizophrenia. However, glucose supplement is not suitable for patients with abnormal metabolic profile. Conclusions: The combination of physical exercise and glucose supplement has potential therapeutic values in treating cognitive impairment in schizophrenia. Further research is necessary to investigate the optimal patterns of exercise and doses of glucose for treating cognitive impairment in schizophrenia. © 2013 Wiley Publishing Asia Pty Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Early Intervention in Psychiatry | - |
dc.subject | Cognitive impairment | - |
dc.subject | Exercise | - |
dc.subject | Schizophrenia | - |
dc.subject | Glucose supplement | - |
dc.title | Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/eip.12109 | - |
dc.identifier.scopus | eid_2-s2.0-84904756814 | - |
dc.identifier.hkuros | 235624 | - |
dc.identifier.hkuros | 229228 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 209 | - |
dc.identifier.epage | 220 | - |
dc.identifier.eissn | 1751-7893 | - |
dc.identifier.isi | WOS:000339799400002 | - |
dc.identifier.issnl | 1751-7885 | - |