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- Publisher Website: 10.1016/S0024-3205(02)02332-9
- Scopus: eid_2-s2.0-0037427874
- PMID: 12493573
- WOS: WOS:000180332900007
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Article: Effect of polysaccharides from Angelica sinensis on gastric ulcer healing
Title | Effect of polysaccharides from Angelica sinensis on gastric ulcer healing |
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Authors | |
Keywords | Polysaccharides Mucus Gastric ulcer Angiogenesis Angelica sinensis |
Issue Date | 2003 |
Citation | Life Sciences, 2003, v. 72, n. 8, p. 925-932 How to Cite? |
Abstract | Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated. © 2002 Elsevier Science Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/207485 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ye, Yini | - |
dc.contributor.author | So, HauLeung | - |
dc.contributor.author | Liu, Edgar Shiu Lam | - |
dc.contributor.author | Shin, Vivianyvonne | - |
dc.contributor.author | Cho, Chihin | - |
dc.date.accessioned | 2014-12-31T01:01:46Z | - |
dc.date.available | 2014-12-31T01:01:46Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Life Sciences, 2003, v. 72, n. 8, p. 925-932 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207485 | - |
dc.description.abstract | Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated. © 2002 Elsevier Science Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Life Sciences | - |
dc.subject | Polysaccharides | - |
dc.subject | Mucus | - |
dc.subject | Gastric ulcer | - |
dc.subject | Angiogenesis | - |
dc.subject | Angelica sinensis | - |
dc.title | Effect of polysaccharides from Angelica sinensis on gastric ulcer healing | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0024-3205(02)02332-9 | - |
dc.identifier.pmid | 12493573 | - |
dc.identifier.scopus | eid_2-s2.0-0037427874 | - |
dc.identifier.hkuros | 76682 | - |
dc.identifier.volume | 72 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 925 | - |
dc.identifier.epage | 932 | - |
dc.identifier.isi | WOS:000180332900007 | - |
dc.identifier.issnl | 0024-3205 | - |