File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.gde.2013.05.003
- Scopus: eid_2-s2.0-84883455409
- PMID: 23747034
- WOS: WOS:000324362900011
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Planar cell polarity in vertebrate limb morphogenesis
Title | Planar cell polarity in vertebrate limb morphogenesis |
---|---|
Authors | |
Keywords | Animals Cell Polarity/*genetics Extremities/*growth & development Models, Theoretical Morphogenesis/*genetics Signal Transduction Vertebrates/growth & development Wnt Proteins/*genetics |
Issue Date | 2013 |
Citation | Current Opinion in Genetics and Development, 2013, v. 23 n. 4, p. 438-444 How to Cite? |
Abstract | Studies of the vertebrate limb development have contributed significantly to understanding the fundamental mechanisms underlying growth, patterning, and morphogenesis of a complex multicellular organism. In the limb, well-defined signaling centers interact to coordinate limb growth and patterning along the three axes. Recent analyses of live imaging and mathematical modeling have provided evidence that polarized cell behaviors governed by morphogen gradients play an important role in shaping the limb bud. Furthermore, the Wnt/planar cell polarity (PCP) pathway that controls uniformly polarized cell behaviors in a field of cells has emerged to be critical for directional morphogenesis in the developing limb. Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner. |
Persistent Identifier | http://hdl.handle.net/10722/208442 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 2.510 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gao, B | en_US |
dc.contributor.author | Yang, Y | en_US |
dc.date.accessioned | 2015-03-11T03:01:02Z | - |
dc.date.available | 2015-03-11T03:01:02Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Current Opinion in Genetics and Development, 2013, v. 23 n. 4, p. 438-444 | en_US |
dc.identifier.issn | 1879-0380 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/208442 | - |
dc.description.abstract | Studies of the vertebrate limb development have contributed significantly to understanding the fundamental mechanisms underlying growth, patterning, and morphogenesis of a complex multicellular organism. In the limb, well-defined signaling centers interact to coordinate limb growth and patterning along the three axes. Recent analyses of live imaging and mathematical modeling have provided evidence that polarized cell behaviors governed by morphogen gradients play an important role in shaping the limb bud. Furthermore, the Wnt/planar cell polarity (PCP) pathway that controls uniformly polarized cell behaviors in a field of cells has emerged to be critical for directional morphogenesis in the developing limb. Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Current Opinion in Genetics and Development | en_US |
dc.subject | Animals | en_US |
dc.subject | Cell Polarity/*genetics | en_US |
dc.subject | Extremities/*growth & development | en_US |
dc.subject | Models, Theoretical | en_US |
dc.subject | Morphogenesis/*genetics | en_US |
dc.subject | Signal Transduction | en_US |
dc.subject | Vertebrates/growth & development | en_US |
dc.subject | Wnt Proteins/*genetics | en_US |
dc.title | Planar cell polarity in vertebrate limb morphogenesis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Gao, B: gaobo@hku.hk | en_US |
dc.identifier.authority | Gao, B=rp02012 | en_US |
dc.identifier.doi | 10.1016/j.gde.2013.05.003 | en_US |
dc.identifier.pmid | 23747034 | - |
dc.identifier.pmcid | PMC3759593 | - |
dc.identifier.scopus | eid_2-s2.0-84883455409 | - |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 438 | en_US |
dc.identifier.epage | 444 | en_US |
dc.identifier.isi | WOS:000324362900011 | - |
dc.identifier.issnl | 0959-437X | - |