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- Publisher Website: 10.1016/B978-0-12-394592-1.00008-9
- Scopus: eid_2-s2.0-84868665485
- PMID: 23140633
- WOS: WOS:000314133400012
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Article: Wnt regulation of planar cell polarity (PCP)
Title | Wnt regulation of planar cell polarity (PCP) |
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Authors | |
Keywords | Animals Cell Movement *Cell Polarity Drosophila/embryology/genetics/metabolism Drosophila Proteins/genetics/metabolism Embryonic Development *Gene Expression Regulation, Developmental Hair/metabolism Mice Nerve Tissue Proteins/genetics/metabolism Neural Tube Defects/metabolism/pathology Receptor Protein-Tyrosine Kinases/genetics/metabolism Wing/cytology/metabolism Wnt Proteins/genetics/metabolism *Wnt Signaling Pathway Zebrafish/embryology/genetics/metabolism Zebrafish Proteins/genetics/metabolism |
Issue Date | 2012 |
Citation | Current Topics in Developmental Biology, 2012, v. 101, p. 263-295 How to Cite? |
Abstract | Planar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular behaviors in a field of cells, has been identified to be critically required for many fundamental developmental processes. However, a global directional cue that establishes PCP in a three-dimensional tissue or organ with respect to the body axes remains elusive. In vertebrate, while Wnt-secreted signaling molecules have been implicated in regulating PCP in a beta-catenin-independent manner, whether they function permissively or act as a global cue to convey directional information is not clearly defined. In addition, the underlying molecular mechanism by which Wnt signal is transduced to core PCP proteins is largely unknown. In this chapter, I review the roles of Wnt signaling in regulating PCP during vertebrate development and update our knowledge of its regulatory mechanism. |
Persistent Identifier | http://hdl.handle.net/10722/208443 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gao, B | en_US |
dc.date.accessioned | 2015-03-11T03:01:03Z | - |
dc.date.available | 2015-03-11T03:01:03Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Current Topics in Developmental Biology, 2012, v. 101, p. 263-295 | en_US |
dc.identifier.issn | 1557-8933 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/208443 | - |
dc.description.abstract | Planar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular behaviors in a field of cells, has been identified to be critically required for many fundamental developmental processes. However, a global directional cue that establishes PCP in a three-dimensional tissue or organ with respect to the body axes remains elusive. In vertebrate, while Wnt-secreted signaling molecules have been implicated in regulating PCP in a beta-catenin-independent manner, whether they function permissively or act as a global cue to convey directional information is not clearly defined. In addition, the underlying molecular mechanism by which Wnt signal is transduced to core PCP proteins is largely unknown. In this chapter, I review the roles of Wnt signaling in regulating PCP during vertebrate development and update our knowledge of its regulatory mechanism. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Current Topics in Developmental Biology | en_US |
dc.subject | Animals | en_US |
dc.subject | Cell Movement | en_US |
dc.subject | *Cell Polarity | en_US |
dc.subject | Drosophila/embryology/genetics/metabolism | en_US |
dc.subject | Drosophila Proteins/genetics/metabolism | en_US |
dc.subject | Embryonic Development | en_US |
dc.subject | *Gene Expression Regulation, Developmental | en_US |
dc.subject | Hair/metabolism | en_US |
dc.subject | Mice | en_US |
dc.subject | Nerve Tissue Proteins/genetics/metabolism | en_US |
dc.subject | Neural Tube Defects/metabolism/pathology | en_US |
dc.subject | Receptor Protein-Tyrosine Kinases/genetics/metabolism | en_US |
dc.subject | Wing/cytology/metabolism | en_US |
dc.subject | Wnt Proteins/genetics/metabolism | en_US |
dc.subject | *Wnt Signaling Pathway | en_US |
dc.subject | Zebrafish/embryology/genetics/metabolism | en_US |
dc.subject | Zebrafish Proteins/genetics/metabolism | en_US |
dc.title | Wnt regulation of planar cell polarity (PCP) | en_US |
dc.type | Article | en_US |
dc.identifier.email | Gao, B: gaobo@hku.hk | en_US |
dc.identifier.authority | Gao, B=rp02012 | en_US |
dc.identifier.doi | 10.1016/B978-0-12-394592-1.00008-9 | en_US |
dc.identifier.pmid | 23140633 | - |
dc.identifier.scopus | eid_2-s2.0-84868665485 | - |
dc.identifier.volume | 101 | en_US |
dc.identifier.spage | 263 | en_US |
dc.identifier.epage | 295 | en_US |
dc.identifier.isi | WOS:000314133400012 | - |
dc.identifier.issnl | 0070-2153 | - |