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- Publisher Website: 10.1128/JVI.00446-15
- Scopus: eid_2-s2.0-84929619188
- PMID: 25787284
- WOS: WOS:000353907900032
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Article: Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection
Title | Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection |
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Authors | |
Issue Date | 2015 |
Publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ |
Citation | Journal of Virology, 2015, v. 89 n. 11, p. 6117-6120 How to Cite? |
Abstract | Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody. |
Persistent Identifier | http://hdl.handle.net/10722/209992 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, J | - |
dc.contributor.author | Perera, RAPM | - |
dc.contributor.author | Kayali, G | - |
dc.contributor.author | Meyerholz, D | - |
dc.contributor.author | Perlman, S | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Sandri-Goldin, RM | - |
dc.date.accessioned | 2015-05-18T03:39:19Z | - |
dc.date.available | 2015-05-18T03:39:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Journal of Virology, 2015, v. 89 n. 11, p. 6117-6120 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10722/209992 | - |
dc.description.abstract | Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody. | - |
dc.language | eng | - |
dc.publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | - |
dc.relation.ispartof | Journal of Virology | - |
dc.rights | Journal of Virology. Copyright © American Society for Microbiology. | - |
dc.title | Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection | - |
dc.type | Article | - |
dc.identifier.email | Perera, RAPM: mahenp@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.authority | Perera, RAPM=rp02500 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JVI.00446-15 | - |
dc.identifier.pmid | 25787284 | - |
dc.identifier.scopus | eid_2-s2.0-84929619188 | - |
dc.identifier.hkuros | 243343 | - |
dc.identifier.volume | 89 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 6117 | - |
dc.identifier.epage | 6120 | - |
dc.identifier.isi | WOS:000353907900032 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-538X | - |