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- Publisher Website: 10.1007/s00417-014-2866-1
- Scopus: eid_2-s2.0-84941878612
- PMID: 25418036
- WOS: WOS:000361397200006
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Article: Quantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg?
Title | Quantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg? |
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Authors | |
Keywords | Silicone oil Emulsification Coulter counter Tamponade |
Issue Date | 2015 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm |
Citation | Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 10, p. 1671-1675 How to Cite? |
Abstract | Purpose
Emulsification of silicone oil in the eye is a difficult problem. In an effort to find an objective way to quantify emulsification, we used the Coulter principle to measure silicone oil emulsified droplets from the washings of a series of patients.
Methods
Aqueous washouts after silicone oil removal were obtained from nine patients (nine eyes). We used the Coulter counter Multisizer® 4 to obtain the size distribution of the oil droplets.
Results
Over 65 % of the emulsified silicone oil droplets in the clinical samples had a diameter smaller than is detectable by light microscopy (2 μm). The median size of the droplets was between 1.1 and 1.9 μm. Based on the Spearman’s correlation coefficient (r), there was a strong correlation between the number of the droplets that cannot be seen (between 1 and 2 μm) and those that can be seen (7–30 μm) (r = 0.817, p = 0.007).
Conclusion
Once emulsification was detected clinically in the anterior chamber, extensive emulsification would have already occurred in the posterior chamber, with most of the emulsified droplets that were too small in size to be seen on clinical examination. Ostwald ripening might explain why there were so many small droplets. The predominance of small droplets might account for some of the clinical complications associated with silicone oil use. |
Persistent Identifier | http://hdl.handle.net/10722/210004 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 1.014 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, YK | - |
dc.contributor.author | Cheung, ND | - |
dc.contributor.author | Chan, WSC | - |
dc.contributor.author | Wong, DSH | - |
dc.date.accessioned | 2015-05-18T03:40:23Z | - |
dc.date.available | 2015-05-18T03:40:23Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 10, p. 1671-1675 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | http://hdl.handle.net/10722/210004 | - |
dc.description.abstract | Purpose Emulsification of silicone oil in the eye is a difficult problem. In an effort to find an objective way to quantify emulsification, we used the Coulter principle to measure silicone oil emulsified droplets from the washings of a series of patients. Methods Aqueous washouts after silicone oil removal were obtained from nine patients (nine eyes). We used the Coulter counter Multisizer® 4 to obtain the size distribution of the oil droplets. Results Over 65 % of the emulsified silicone oil droplets in the clinical samples had a diameter smaller than is detectable by light microscopy (2 μm). The median size of the droplets was between 1.1 and 1.9 μm. Based on the Spearman’s correlation coefficient (r), there was a strong correlation between the number of the droplets that cannot be seen (between 1 and 2 μm) and those that can be seen (7–30 μm) (r = 0.817, p = 0.007). Conclusion Once emulsification was detected clinically in the anterior chamber, extensive emulsification would have already occurred in the posterior chamber, with most of the emulsified droplets that were too small in size to be seen on clinical examination. Ostwald ripening might explain why there were so many small droplets. The predominance of small droplets might account for some of the clinical complications associated with silicone oil use. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm | - |
dc.relation.ispartof | Graefe's Archive for Clinical and Experimental Ophthalmology | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s00417-014-2866-1 | - |
dc.subject | Silicone oil | - |
dc.subject | Emulsification | - |
dc.subject | Coulter counter | - |
dc.subject | Tamponade | - |
dc.title | Quantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg? | - |
dc.type | Article | - |
dc.identifier.email | Chan, YK: josephyk@connect.hku.hk | - |
dc.identifier.email | Cheung, ND: dc555@hku.hk | - |
dc.identifier.email | Chan, WSC: cath0320@hkucc.hku.hk | - |
dc.identifier.email | Wong, DSH: shdwong@hku.hk | - |
dc.identifier.authority | Chan, YK=rp02536 | - |
dc.identifier.authority | Cheung, ND=rp01752 | - |
dc.identifier.authority | Wong, DSH=rp00516 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00417-014-2866-1 | - |
dc.identifier.pmid | 25418036 | - |
dc.identifier.scopus | eid_2-s2.0-84941878612 | - |
dc.identifier.hkuros | 243292 | - |
dc.identifier.volume | 253 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1671 | - |
dc.identifier.epage | 1675 | - |
dc.identifier.isi | WOS:000361397200006 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0721-832X | - |