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- Publisher Website: 10.1007/s11684-015-0408-9
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- PMID: 26276037
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Article: TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma
Title | TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma |
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Authors | |
Keywords | TCGA HCC liver cancer whole-transcriptome sequencing |
Issue Date | 2015 |
Publisher | Higher Education Press. The Journal's web site is located at http://www.springer.com/medicine/journal/11684 |
Citation | Frontiers of Medicine, 2015, v. 9, n. 3, p. 322-330 How to Cite? |
Abstract | This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma (HCC) by comparing the global gene expression profiles between tumors and their corresponding nontumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated (CENPF and FOXM1) and downregulated (CLEC4G, CRHBP, and CLEC1B) genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization. |
Persistent Identifier | http://hdl.handle.net/10722/212083 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, DWH | - |
dc.contributor.author | Kai, AKL | - |
dc.contributor.author | Ng, IOL | - |
dc.date.accessioned | 2015-07-21T02:22:26Z | - |
dc.date.available | 2015-07-21T02:22:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Frontiers of Medicine, 2015, v. 9, n. 3, p. 322-330 | - |
dc.identifier.issn | 2095-0217 | - |
dc.identifier.uri | http://hdl.handle.net/10722/212083 | - |
dc.description.abstract | This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma (HCC) by comparing the global gene expression profiles between tumors and their corresponding nontumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated (CENPF and FOXM1) and downregulated (CLEC4G, CRHBP, and CLEC1B) genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization. | - |
dc.language | eng | - |
dc.publisher | Higher Education Press. The Journal's web site is located at http://www.springer.com/medicine/journal/11684 | - |
dc.relation.ispartof | Frontiers of Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | TCGA | - |
dc.subject | HCC | - |
dc.subject | liver cancer | - |
dc.subject | whole-transcriptome sequencing | - |
dc.title | TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Ho, DWH: dwhho@hku.hk | - |
dc.identifier.email | Kai, AKL: klakai@hku.hk | - |
dc.identifier.email | Ng, IOL: iolng@hku.hk | - |
dc.identifier.authority | Ng, IOL=rp00335 | - |
dc.identifier.doi | 10.1007/s11684-015-0408-9 | - |
dc.identifier.pmid | 26276037 | - |
dc.identifier.scopus | eid_2-s2.0-84973434305 | - |
dc.identifier.hkuros | 244516 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 322 | - |
dc.identifier.epage | 330 | - |
dc.identifier.isi | WOS:000368445200006 | - |
dc.publisher.place | Berlin | - |
dc.identifier.issnl | 2095-0217 | - |