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Article: Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
Title | Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus |
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Authors | |
Keywords | Anti-nuclear autoantibody (ANA) B-1 B cells Germinal center B cells (GC B cells) Marginal zone B cells (MZ B cells) Memory B cells Myeloid differentiation primary response gene 88 (MyD88) Systemic lupus erythematosus (SLE) Toll-like receptor (TLR) Transitional B cells Unc-93 Homolog B1 (C. elegans) (Unc93b1) |
Issue Date | 2015 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2015, v. 16 n. 6, p. 13084-13105 How to Cite? |
Abstract | Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted. |
Persistent Identifier | http://hdl.handle.net/10722/212118 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, K | - |
dc.contributor.author | Li, J | - |
dc.contributor.author | Fang, Y | - |
dc.contributor.author | Lu, L | - |
dc.date.accessioned | 2015-07-21T02:23:35Z | - |
dc.date.available | 2015-07-21T02:23:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2015, v. 16 n. 6, p. 13084-13105 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/10722/212118 | - |
dc.description.abstract | Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Anti-nuclear autoantibody (ANA) | - |
dc.subject | B-1 B cells | - |
dc.subject | Germinal center B cells (GC B cells) | - |
dc.subject | Marginal zone B cells (MZ B cells) | - |
dc.subject | Memory B cells | - |
dc.subject | Myeloid differentiation primary response gene 88 (MyD88) | - |
dc.subject | Systemic lupus erythematosus (SLE) | - |
dc.subject | Toll-like receptor (TLR) | - |
dc.subject | Transitional B cells | - |
dc.subject | Unc-93 Homolog B1 (C. elegans) (Unc93b1) | - |
dc.title | Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus | - |
dc.type | Article | - |
dc.identifier.email | Ma, K: kongyang@hku.hk | - |
dc.identifier.email | Lu, L: liweilu@hkucc.hku.hk | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms160613084 | - |
dc.identifier.pmid | 26068236 | - |
dc.identifier.pmcid | PMC4490487 | - |
dc.identifier.scopus | eid_2-s2.0-84931269995 | - |
dc.identifier.hkuros | 245001 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 13084 | - |
dc.identifier.epage | 13105 | - |
dc.identifier.isi | WOS:000357492800071 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1422-0067 | - |