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- Publisher Website: 10.1109/NEMS.2007.352217
- Scopus: eid_2-s2.0-34548137661
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Conference Paper: Recognition of membrane receptor by atomic force microscopy
| Title | Recognition of membrane receptor by atomic force microscopy |
|---|---|
| Authors | |
| Keywords | Membrane protein AFM AT1 receptor |
| Issue Date | 2007 |
| Citation | Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, 2007, p. 1133-1136 How to Cite? |
| Abstract | Membrane receptors play important roles in the signal pathway to regulate cell functions, and therefore, they are usually the main drug targets. However, the study of cell membrane receptors in situ on molecular level is difficult due to the current technical limitations. The recent development of atomic force microscopy (AFM) opens a new way to study the functionalities of cell membrane receptors. In this paper, techniques involving the use of AFM to probe the membrane proteins are introduced. The technique for characterizing specific single receptor using the functionalized AFM tip is discussed. An example of probing angiotensin II type 1 (AT1) receptor on sensory neuron's membrane is also given in this paper. © 2007 IEEE. |
| Persistent Identifier | http://hdl.handle.net/10722/212937 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, Guangyong | - |
| dc.contributor.author | Xi, Ning | - |
| dc.contributor.author | Wang, Donna H. | - |
| dc.date.accessioned | 2015-07-28T04:05:30Z | - |
| dc.date.available | 2015-07-28T04:05:30Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier.citation | Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, 2007, p. 1133-1136 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/212937 | - |
| dc.description.abstract | Membrane receptors play important roles in the signal pathway to regulate cell functions, and therefore, they are usually the main drug targets. However, the study of cell membrane receptors in situ on molecular level is difficult due to the current technical limitations. The recent development of atomic force microscopy (AFM) opens a new way to study the functionalities of cell membrane receptors. In this paper, techniques involving the use of AFM to probe the membrane proteins are introduced. The technique for characterizing specific single receptor using the functionalized AFM tip is discussed. An example of probing angiotensin II type 1 (AT1) receptor on sensory neuron's membrane is also given in this paper. © 2007 IEEE. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 | - |
| dc.subject | Membrane protein | - |
| dc.subject | AFM | - |
| dc.subject | AT1 receptor | - |
| dc.title | Recognition of membrane receptor by atomic force microscopy | - |
| dc.type | Conference_Paper | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1109/NEMS.2007.352217 | - |
| dc.identifier.scopus | eid_2-s2.0-34548137661 | - |
| dc.identifier.spage | 1133 | - |
| dc.identifier.epage | 1136 | - |