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Conference Paper: An AFM method for in situ probing membrane proteins under physiological condition

TitleAn AFM method for in situ probing membrane proteins under physiological condition
Authors
Li, GuangyongXi, NingChan, Ho YinWang, Donna H.
Issue Date2006
Citation
2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006, 2006, v. 1, p. 181-184 How to Cite?
AbstractAlthough membrane proteins are the main drug targets, the study of cell membrane proteins in situ at the molecular level is difficult due to the current technical limitations. The recent development of atomic force microscopy (AFM) opens a new avenue to study the functionalities of cell membrane proteins. In this paper, techniques involving the use of AFM to probe biomolecules are introduced. The techniques for characterizing specific single receptor using the functionalized AFM tip is discussed. An example of probing angiotensin II type 1 (AT1) receptor by functionalized AFM tip is also given in this paper. © 2006 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/212966

 

DC FieldValueLanguage
dc.contributor.authorLi, Guangyong-
dc.contributor.authorXi, Ning-
dc.contributor.authorChan, Ho Yin-
dc.contributor.authorWang, Donna H.-
dc.date.accessioned2015-07-28T04:05:36Z-
dc.date.available2015-07-28T04:05:36Z-
dc.date.issued2006-
dc.identifier.citation2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006, 2006, v. 1, p. 181-184-
dc.identifier.urihttp://hdl.handle.net/10722/212966-
dc.description.abstractAlthough membrane proteins are the main drug targets, the study of cell membrane proteins in situ at the molecular level is difficult due to the current technical limitations. The recent development of atomic force microscopy (AFM) opens a new avenue to study the functionalities of cell membrane proteins. In this paper, techniques involving the use of AFM to probe biomolecules are introduced. The techniques for characterizing specific single receptor using the functionalized AFM tip is discussed. An example of probing angiotensin II type 1 (AT1) receptor by functionalized AFM tip is also given in this paper. © 2006 IEEE.-
dc.languageeng-
dc.relation.ispartof2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006-
dc.titleAn AFM method for in situ probing membrane proteins under physiological condition-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-42549115749-
dc.identifier.volume1-
dc.identifier.spage181-
dc.identifier.epage184-

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