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Conference Paper: Growth and endocrine disrupting effects of the mycotoxins zeralenone and aflatoxin B1 on breast cancer cells
| Title | Growth and endocrine disrupting effects of the mycotoxins zeralenone and aflatoxin B1 on breast cancer cells |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Publisher | The University of Hong Kong. |
| Citation | The 1st International Conference on Food Safety: From Experience to Perspectives (ICFS 2014), The University of Hong Kong, Hong Kong, 14-18 June 2014. In Conference Proceedings, 2014, p. 95, abstract no. P18 How to Cite? |
| Abstract | Zearalenone (ZEA) and aflatoxin B1 (AFB1) are secondary metabolites produced by the fungi Fusarium and Aspergillus respectively. ZEA is proven to be an estrogenic endocrine disruptor since 1950s, while AFB1 is recently found to disrupt steroidogenesis in placenta. Both mycotoxins are constant contaminants of cereals worldwide and can both be found at significant levels in human plasma/urine of people in developing countries. Due to the co-occurrence of ZEA and AFB1 in food and human samples and the possibility of endocrine disruptors to modulate the growth of hormonal dependent breast cancer, we hypothesized that exposure to ZEA and AFB1 would affect the growth and cell cycle progression of breast cancer cells by modulating gene expressions and disrupting steroidogenesis and hormone … |
| Persistent Identifier | http://hdl.handle.net/10722/213632 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yip, KY | - |
| dc.contributor.author | Wong, AST | - |
| dc.contributor.author | El-Nezamy, H | - |
| dc.date.accessioned | 2015-08-07T06:58:05Z | - |
| dc.date.available | 2015-08-07T06:58:05Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | The 1st International Conference on Food Safety: From Experience to Perspectives (ICFS 2014), The University of Hong Kong, Hong Kong, 14-18 June 2014. In Conference Proceedings, 2014, p. 95, abstract no. P18 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/213632 | - |
| dc.description.abstract | Zearalenone (ZEA) and aflatoxin B1 (AFB1) are secondary metabolites produced by the fungi Fusarium and Aspergillus respectively. ZEA is proven to be an estrogenic endocrine disruptor since 1950s, while AFB1 is recently found to disrupt steroidogenesis in placenta. Both mycotoxins are constant contaminants of cereals worldwide and can both be found at significant levels in human plasma/urine of people in developing countries. Due to the co-occurrence of ZEA and AFB1 in food and human samples and the possibility of endocrine disruptors to modulate the growth of hormonal dependent breast cancer, we hypothesized that exposure to ZEA and AFB1 would affect the growth and cell cycle progression of breast cancer cells by modulating gene expressions and disrupting steroidogenesis and hormone … | - |
| dc.language | eng | - |
| dc.publisher | The University of Hong Kong. | - |
| dc.relation.ispartof | International Conference on Food Safety, ICFS 2014 | - |
| dc.title | Growth and endocrine disrupting effects of the mycotoxins zeralenone and aflatoxin B1 on breast cancer cells | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wong, AST: awong1@hku.hk | - |
| dc.identifier.email | El-Nezamy, H: elnezami@hkucc.hku.hk | - |
| dc.identifier.authority | Wong, AST=rp00805 | - |
| dc.identifier.authority | El-Nezamy, H=rp00694 | - |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 247732 | - |
| dc.identifier.spage | 95, abstract no. P18 | - |
| dc.identifier.epage | 95, abstract no. P18 | - |
| dc.publisher.place | Hong Kong | - |