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Conference Paper: Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction

TitleDeletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction
Authors
Gu, PHui, HXVanhoutte, PMLam, KSLXu, A
Issue Date2015
PublisherThe University of Hong Kong.
Citation
The 1st Joint Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS), The University of Hong Kong, Hong Kong, China, 19-21 May 2015. In Poster Abstracts, 2015, p. 22, abstract no. 507 How to Cite?
AbstractINTRODUCTION: Perivascular adipose tissue (PVAT) exhibits brown adipose features and its dysfunction is implicated in cardiovascular diseases. SIRT1 is key to adipocyte phenotypes and metabolism. AIMS: In the present study, we aim to investigate the role of SIRT1 within PVAT in modulating obesity-evoked endothelial dysfunction. Methods. Wild type (WT) and adipocyte-specific SIRT1 knockout mice (AKO) were fed with standard chow or westernized diet for 12 weeks. Endothelium-dependent relaxation (EDR) in aortic rings with or without PVAT was assessed by wire myograph. DHE staining was …
DescriptionConference Theme: Tomorrow’s medicines: pharmacology, patients and populations
Persistent Identifierhttp://hdl.handle.net/10722/213680

 

DC FieldValueLanguage
dc.contributor.authorGu, P-
dc.contributor.authorHui, HX-
dc.contributor.authorVanhoutte, PM-
dc.contributor.authorLam, KSL-
dc.contributor.authorXu, A-
dc.date.accessioned2015-08-11T07:47:50Z-
dc.date.available2015-08-11T07:47:50Z-
dc.date.issued2015-
dc.identifier.citationThe 1st Joint Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS), The University of Hong Kong, Hong Kong, China, 19-21 May 2015. In Poster Abstracts, 2015, p. 22, abstract no. 507-
dc.identifier.urihttp://hdl.handle.net/10722/213680-
dc.descriptionConference Theme: Tomorrow’s medicines: pharmacology, patients and populations-
dc.description.abstractINTRODUCTION: Perivascular adipose tissue (PVAT) exhibits brown adipose features and its dysfunction is implicated in cardiovascular diseases. SIRT1 is key to adipocyte phenotypes and metabolism. AIMS: In the present study, we aim to investigate the role of SIRT1 within PVAT in modulating obesity-evoked endothelial dysfunction. Methods. Wild type (WT) and adipocyte-specific SIRT1 knockout mice (AKO) were fed with standard chow or westernized diet for 12 weeks. Endothelium-dependent relaxation (EDR) in aortic rings with or without PVAT was assessed by wire myograph. DHE staining was …-
dc.languageeng-
dc.publisherThe University of Hong Kong.-
dc.relation.ispartof1st ASCEPT-BPS Joint Scientific Meeting-
dc.titleDeletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction-
dc.typeConference_Paper-
dc.identifier.emailGu, P: ping1976@hku.hk-
dc.identifier.emailHui, HX: hannahui@hkucc.hku.hk-
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityVanhoutte, PM=rp00238-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros247633-
dc.identifier.spage22, abstract no. 507-
dc.identifier.epage22, abstract no. 507-
dc.publisher.placeHong Kong-

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