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- Publisher Website: 10.1016/j.radonc.2011.05.022
- Scopus: eid_2-s2.0-84455161150
- PMID: 21640423
- WOS: WOS:000300654700010
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Article: Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control
Title | Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control |
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Authors | |
Keywords | Liver cancer Respiratory control Radiotherapy Liver neoplasm Image-guided radiotherapy Hepatocellular Carcinoma |
Issue Date | 2012 |
Citation | Radiotherapy and Oncology, 2012, v. 102, n. 1, p. 56-61 How to Cite? |
Abstract | Purpose: To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. Materials and methods: CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Results: Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months). Conclusions: Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. © 2011 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/213958 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.702 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Law, Ada L Y | - |
dc.contributor.author | Ng, Wai Tong | - |
dc.contributor.author | Lee, Michael C H | - |
dc.contributor.author | Chan, Augustine T S | - |
dc.contributor.author | Fung, Kai Hung | - |
dc.contributor.author | Li, Francis | - |
dc.contributor.author | Lao, Wai Cheung | - |
dc.contributor.author | Lee, Anne W M | - |
dc.date.accessioned | 2015-08-19T13:41:22Z | - |
dc.date.available | 2015-08-19T13:41:22Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Radiotherapy and Oncology, 2012, v. 102, n. 1, p. 56-61 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213958 | - |
dc.description.abstract | Purpose: To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. Materials and methods: CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Results: Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months). Conclusions: Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. © 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Radiotherapy and Oncology | - |
dc.subject | Liver cancer | - |
dc.subject | Respiratory control | - |
dc.subject | Radiotherapy | - |
dc.subject | Liver neoplasm | - |
dc.subject | Image-guided radiotherapy | - |
dc.subject | Hepatocellular | - |
dc.subject | Carcinoma | - |
dc.title | Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.radonc.2011.05.022 | - |
dc.identifier.pmid | 21640423 | - |
dc.identifier.scopus | eid_2-s2.0-84455161150 | - |
dc.identifier.hkuros | 266358 | - |
dc.identifier.volume | 102 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 56 | - |
dc.identifier.epage | 61 | - |
dc.identifier.eissn | 1879-0887 | - |
dc.identifier.isi | WOS:000300654700010 | - |
dc.identifier.issnl | 0167-8140 | - |