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- Publisher Website: 10.1016/j.oraloncology.2011.12.001
- Scopus: eid_2-s2.0-84860013938
- PMID: 22206807
- WOS: WOS:000303104800011
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Article: A phase II study of pemetrexed combined with cisplatin in patients with recurrent or metastatic nanopharyngeal carcinoma
Title | A phase II study of pemetrexed combined with cisplatin in patients with recurrent or metastatic nanopharyngeal carcinoma |
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Authors | |
Keywords | Chemotherapy Cisplatin Metastasis Nasopharyngeal carcinoma Neoplasm recurrence Pemetrexed |
Issue Date | 2012 |
Citation | Oral Oncology, 2012, v. 48, n. 5, p. 441-444 How to Cite? |
Abstract | Pemetrexed is a novel chemotherapy agent with good efficacy and toxicity profiles. This phase II study aimed at evaluating its use in combination with cisplatin for recurrent or metastatic nasopharyngeal carcinoma (NPC). All participating patients had metastatic or recurrent NPC with prior treatment by platinum-based chemotherapy. The study regimen comprised of pemetrexed 500 mg/m 2 and cisplatin 75 mg/m 2, repeated 3-weekly for 4 cycles. Efficacy evaluation was based on both radiological and biochemical responses. Patients with no progressive disease and good tolerance were given another 2-4 cycles. Fifteen patients were treated for a total of 4-8 cycles (median, 6 cycles); 9 had distant metastases and 6 had loco-regional recurrences only. Reduction of DNA copies of EB virus by ≥50% was observed in 93% accessible patients, with 21% of them being biochemical complete response (CR). Radiologically, 1 (7%) patient achieved CR, 2 (13%) achieved partial response and 8 (53%) had stable diseases. The median time to progression was 30 weeks. Treatment was well tolerated with only 1 (7%) patient developing grade 4 toxicity (of anemia). The most common grade 3 toxicities were neutropenia (27%) and anemia (20%). The baseline mean total QOL scores (as measured with FACT-H&N version 4) was 100.4 and showed no significant change after the fourth cycle (95.6, p = 0.20) and sixth cycle (91.9, p = 0.15). Pemetrexed in combination with cisplatin is a well tolerated regimen with encouraging efficacy for metastatic and recurrent NPC. Further evaluation of its role in the management of NPC is warranted. © 2011 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/213963 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yau, T. K. | - |
dc.contributor.author | Shum, T. | - |
dc.contributor.author | Lee, A. W M | - |
dc.contributor.author | Yeung, M. W. | - |
dc.contributor.author | Ng, W. T. | - |
dc.contributor.author | Chan, L. | - |
dc.date.accessioned | 2015-08-19T13:41:23Z | - |
dc.date.available | 2015-08-19T13:41:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Oral Oncology, 2012, v. 48, n. 5, p. 441-444 | - |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213963 | - |
dc.description.abstract | Pemetrexed is a novel chemotherapy agent with good efficacy and toxicity profiles. This phase II study aimed at evaluating its use in combination with cisplatin for recurrent or metastatic nasopharyngeal carcinoma (NPC). All participating patients had metastatic or recurrent NPC with prior treatment by platinum-based chemotherapy. The study regimen comprised of pemetrexed 500 mg/m 2 and cisplatin 75 mg/m 2, repeated 3-weekly for 4 cycles. Efficacy evaluation was based on both radiological and biochemical responses. Patients with no progressive disease and good tolerance were given another 2-4 cycles. Fifteen patients were treated for a total of 4-8 cycles (median, 6 cycles); 9 had distant metastases and 6 had loco-regional recurrences only. Reduction of DNA copies of EB virus by ≥50% was observed in 93% accessible patients, with 21% of them being biochemical complete response (CR). Radiologically, 1 (7%) patient achieved CR, 2 (13%) achieved partial response and 8 (53%) had stable diseases. The median time to progression was 30 weeks. Treatment was well tolerated with only 1 (7%) patient developing grade 4 toxicity (of anemia). The most common grade 3 toxicities were neutropenia (27%) and anemia (20%). The baseline mean total QOL scores (as measured with FACT-H&N version 4) was 100.4 and showed no significant change after the fourth cycle (95.6, p = 0.20) and sixth cycle (91.9, p = 0.15). Pemetrexed in combination with cisplatin is a well tolerated regimen with encouraging efficacy for metastatic and recurrent NPC. Further evaluation of its role in the management of NPC is warranted. © 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Oral Oncology | - |
dc.subject | Chemotherapy | - |
dc.subject | Cisplatin | - |
dc.subject | Metastasis | - |
dc.subject | Nasopharyngeal carcinoma | - |
dc.subject | Neoplasm recurrence | - |
dc.subject | Pemetrexed | - |
dc.title | A phase II study of pemetrexed combined with cisplatin in patients with recurrent or metastatic nanopharyngeal carcinoma | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.oraloncology.2011.12.001 | - |
dc.identifier.pmid | 22206807 | - |
dc.identifier.scopus | eid_2-s2.0-84860013938 | - |
dc.identifier.hkuros | 266361 | - |
dc.identifier.volume | 48 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 441 | - |
dc.identifier.epage | 444 | - |
dc.identifier.eissn | 1879-0593 | - |
dc.identifier.isi | WOS:000303104800011 | - |
dc.identifier.issnl | 1368-8375 | - |