File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/chem.201402137
- Scopus: eid_2-s2.0-84925326213
- PMID: 25124716
- WOS: WOS:000342627300043
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Induced Self-Assembly of Platinum(II) Alkynyl Complexes through Specific Interactions between Citrate and Guanidinium for Proof-of-Principle Detection of Citrate and an Assay of Citrate Lyase
Title | Induced Self-Assembly of Platinum(II) Alkynyl Complexes through Specific Interactions between Citrate and Guanidinium for Proof-of-Principle Detection of Citrate and an Assay of Citrate Lyase |
---|---|
Authors | |
Keywords | Anions Luminescence Platinum Self‐assembly Supramolecular chemistry |
Issue Date | 2014 |
Publisher | Wiley - V C H Verlag GmbH & Co. KGaA. |
Citation | Chemistry: A European Journal, 2014, v. 20 n. 40, p. 13016-13027 How to Cite? |
Abstract | Water‐soluble alkynylplatinum(II) terpyridine complexes appended with guanidinium moieties, [Pt(tpy)(CCAr)][OTf]2 (tpy=terpyridine; OTf=trifluoromethanesulfonate; Ar=C6H4‐{NHC(NH2+)(NH2)}‐4 (1), C6H4‐{CH2NHC(NH2+)(NH2)}‐4 (2)), and [Pt(tBu3tpy)(CCC6H4‐{NHC(NH2+)(NH2)}‐4)][OTf]2 (3; tBu3tpy=4,4′,4′′‐tri‐tert‐butyl‐2,2′:6′,2′′‐terpyridine), have been synthesized and characterized. The photophysical properties of the complexes have been studied. Based on the results of UV/Vis absorption, resonance light scattering, and dynamic light scattering experiments, in aqueous buffer solutions complexes 1 and 2 undergo aggregation in the presence of citrate through strong and specific electrostatic and hydrogen‐bonding interactions with citrate. The emergence of a triplet metal–metal‐to‐ligand charge transfer (3MMLCT) emission in the near‐infrared (NIR) region brought on by the induced self‐assembly of complex 1 has been demonstrated for proof‐of‐principle detection of citrate with good sensitivity and selectivity over other mono‐ and dicarboxylate substrates in the tricarboxylic acid (TCA) cycle as well as phosphate and lactate anions. Such a good selectivity toward citrate has been rationalized by the high charge density of citrate under physiological conditions and specific interactions between the guanidinium moiety on complex 1 and citrate. Extension of the work to citrate detection in fetal bovine serum and real‐time monitoring of the activity of citrate lyase by the NIR emission of complex 1 have also been demonstrated. |
Persistent Identifier | http://hdl.handle.net/10722/215097 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.058 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, CYS | - |
dc.contributor.author | Yam, VWW | - |
dc.date.accessioned | 2015-08-21T12:27:13Z | - |
dc.date.available | 2015-08-21T12:27:13Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Chemistry: A European Journal, 2014, v. 20 n. 40, p. 13016-13027 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/10722/215097 | - |
dc.description.abstract | Water‐soluble alkynylplatinum(II) terpyridine complexes appended with guanidinium moieties, [Pt(tpy)(CCAr)][OTf]2 (tpy=terpyridine; OTf=trifluoromethanesulfonate; Ar=C6H4‐{NHC(NH2+)(NH2)}‐4 (1), C6H4‐{CH2NHC(NH2+)(NH2)}‐4 (2)), and [Pt(tBu3tpy)(CCC6H4‐{NHC(NH2+)(NH2)}‐4)][OTf]2 (3; tBu3tpy=4,4′,4′′‐tri‐tert‐butyl‐2,2′:6′,2′′‐terpyridine), have been synthesized and characterized. The photophysical properties of the complexes have been studied. Based on the results of UV/Vis absorption, resonance light scattering, and dynamic light scattering experiments, in aqueous buffer solutions complexes 1 and 2 undergo aggregation in the presence of citrate through strong and specific electrostatic and hydrogen‐bonding interactions with citrate. The emergence of a triplet metal–metal‐to‐ligand charge transfer (3MMLCT) emission in the near‐infrared (NIR) region brought on by the induced self‐assembly of complex 1 has been demonstrated for proof‐of‐principle detection of citrate with good sensitivity and selectivity over other mono‐ and dicarboxylate substrates in the tricarboxylic acid (TCA) cycle as well as phosphate and lactate anions. Such a good selectivity toward citrate has been rationalized by the high charge density of citrate under physiological conditions and specific interactions between the guanidinium moiety on complex 1 and citrate. Extension of the work to citrate detection in fetal bovine serum and real‐time monitoring of the activity of citrate lyase by the NIR emission of complex 1 have also been demonstrated. | - |
dc.language | eng | - |
dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA. | - |
dc.relation.ispartof | Chemistry: A European Journal | - |
dc.subject | Anions | - |
dc.subject | Luminescence | - |
dc.subject | Platinum | - |
dc.subject | Self‐assembly | - |
dc.subject | Supramolecular chemistry | - |
dc.title | Induced Self-Assembly of Platinum(II) Alkynyl Complexes through Specific Interactions between Citrate and Guanidinium for Proof-of-Principle Detection of Citrate and an Assay of Citrate Lyase | - |
dc.type | Article | - |
dc.identifier.email | Chung, CYS: cyschung@hku.hk | - |
dc.identifier.email | Yam, VWW: wwyam@hku.hk | - |
dc.identifier.authority | Chung, CYS=rp02672 | - |
dc.identifier.authority | Yam, VWW=rp00822 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/chem.201402137 | - |
dc.identifier.pmid | 25124716 | - |
dc.identifier.scopus | eid_2-s2.0-84925326213 | - |
dc.identifier.hkuros | 246384 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 40 | - |
dc.identifier.spage | 13016 | - |
dc.identifier.epage | 13027 | - |
dc.identifier.isi | WOS:000342627300043 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0947-6539 | - |