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- Publisher Website: 10.1109/ECC.2014.6862284
- Scopus: eid_2-s2.0-84911468342
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Conference Paper: To boost or not to boost: Immune activation in HIV infection
Title | To boost or not to boost: Immune activation in HIV infection |
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Authors | |
Issue Date | 2014 |
Publisher | IEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6657188 |
Citation | The 13th European Control Conference (ECC 2014), Strasbourg, France, 24-27 June 2014. In Conference Proceedings, 2014, p. 1837–1842 How to Cite? |
Abstract | Various clinical experiments have suggested the significant role of CD4+ T cells activation in viral spread and immune control of HIV infection. In this paper, we use a new mathematical model to explore the intricate interactions among immune activation, CTL response, T cell depletion, and immune escape. It is shown that enhanced immune activation and proliferation of CD4+ T cells, opposite to its beneficial effects in other infections, may facilitate infection and lead to the depletion of CD4+ T cells if effective immune control is not established. By contrast, once effective CTL response to HIV is mounted, the boost of CD4+ T cell response may be beneficial for controlling infection and alleviating immune impairment. Another finding is that immune escape may occur when the infection rate is low, and enhanced activation may prevent the escape if effective immune control can be established. Simulations are provided to illustrate the theoretical analysis. © EUCA |
Description | Open Access |
Persistent Identifier | http://hdl.handle.net/10722/217412 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Shu, Z | - |
dc.contributor.author | Middleton, RH | - |
dc.contributor.author | Chen, MZ | - |
dc.date.accessioned | 2015-09-18T05:58:45Z | - |
dc.date.available | 2015-09-18T05:58:45Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 13th European Control Conference (ECC 2014), Strasbourg, France, 24-27 June 2014. In Conference Proceedings, 2014, p. 1837–1842 | - |
dc.identifier.isbn | 978-3-9524269-1-3 | - |
dc.identifier.uri | http://hdl.handle.net/10722/217412 | - |
dc.description | Open Access | - |
dc.description.abstract | Various clinical experiments have suggested the significant role of CD4+ T cells activation in viral spread and immune control of HIV infection. In this paper, we use a new mathematical model to explore the intricate interactions among immune activation, CTL response, T cell depletion, and immune escape. It is shown that enhanced immune activation and proliferation of CD4+ T cells, opposite to its beneficial effects in other infections, may facilitate infection and lead to the depletion of CD4+ T cells if effective immune control is not established. By contrast, once effective CTL response to HIV is mounted, the boost of CD4+ T cell response may be beneficial for controlling infection and alleviating immune impairment. Another finding is that immune escape may occur when the infection rate is low, and enhanced activation may prevent the escape if effective immune control can be established. Simulations are provided to illustrate the theoretical analysis. © EUCA | - |
dc.language | eng | - |
dc.publisher | IEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6657188 | - |
dc.relation.ispartof | European Control Conference | - |
dc.rights | European Control Conference. Copyright © IEEE. | - |
dc.rights | ©2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | - |
dc.title | To boost or not to boost: Immune activation in HIV infection | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chen, MZ: mzqchen@hku.hk | - |
dc.identifier.authority | Chen, MZ=rp01317 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1109/ECC.2014.6862284 | - |
dc.identifier.scopus | eid_2-s2.0-84911468342 | - |
dc.identifier.hkuros | 250971 | - |
dc.identifier.spage | 1837 | - |
dc.identifier.epage | 1842 | - |
dc.publisher.place | United States | - |
dc.customcontrol.immutable | sml 151105 | - |