File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.jash.2014.07.021
- Find via
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Investigating the relationship between stroke and serum fatty acids in hypertensive population
Title | Investigating the relationship between stroke and serum fatty acids in hypertensive population |
---|---|
Authors | |
Keywords | USFA SFA Stroke Hypertension |
Issue Date | 2014 |
Publisher | Elsevier Inc.. The Journal's web site is located at http://www.ashjournal.com |
Citation | The 29th Annual Scientific Meeting of the American Society of Hypertension, New York, NY., 16-20 May 2014. In Journal of the American Society of Hypertension, 2014, v. 8 n. suppl 1, p. e9, abstract no. LB-P-07 How to Cite? |
Abstract | BACKGROUND: Stroke is prevalent in hypertensive population. It has been suggested that monospecific unsaturated fatty acids (USFA) have potential effect on protection against stroke. However, the effect of saturated fatty acids (SFAs) on stroke is controversial. Therefore, we studied the relationship between recent stroke and serum levels of fatty acids including both USFAs and SFAs in hypertensive patients. METHODS: 89 pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient experiencing a stroke within 48 hours before examination and a hypertensive patient without stroke. 6 categories of serum fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated. Data were analyzed using R version 3.0.1. RESULTS: There were differences in educational level (P¼0.002) and occupation (P<0.001) between stroke and non-stroke participants. Non-stroke participants had higher levels of total cholesterol (P<0.001), triglyceride (P¼0.041), LDL (P¼0.048) and HDL (P¼0.001). All the 6 fatty acid levels were higher in non-stroke participants (P¼0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). Before adjustment, recent stroke was inversely associated with fatty acid levels except lignoceric acid’s. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with recent stroke. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR¼0.965, 95%CI¼0.942-0.990, P¼0.005), behenic acid (OR¼0.778, 95%CI¼0.664-0.939, P¼0.009), nervonic acid (OR¼0.323, 95%CI¼0.121-0.860, P¼0.024) with recent stroke were still highly significant. CONCLUSION: The levels of the fatty acids except lignoceric acid were inversely associated with recent stroke. Our results raise the possibility that both USFAs and SFAs may have beneficial effect on reduction of stroke risk in hypertensive population. |
Description | Late Breaking Poster Abstract: no. LB-P-07 |
Persistent Identifier | http://hdl.handle.net/10722/217540 |
ISSN | 2018 Impact Factor: 2.268 2020 SCImago Journal Rankings: 0.980 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | LI, C | - |
dc.contributor.author | Peng, H | - |
dc.contributor.author | Cai, XQ | - |
dc.contributor.author | Tsang, TK | - |
dc.contributor.author | Shen, HS | - |
dc.contributor.author | Wu, XH | - |
dc.contributor.author | Zhou, YB | - |
dc.contributor.author | Cheung, BMY | - |
dc.date.accessioned | 2015-09-18T06:03:32Z | - |
dc.date.available | 2015-09-18T06:03:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 29th Annual Scientific Meeting of the American Society of Hypertension, New York, NY., 16-20 May 2014. In Journal of the American Society of Hypertension, 2014, v. 8 n. suppl 1, p. e9, abstract no. LB-P-07 | - |
dc.identifier.issn | 1933-1711 | - |
dc.identifier.uri | http://hdl.handle.net/10722/217540 | - |
dc.description | Late Breaking Poster Abstract: no. LB-P-07 | - |
dc.description.abstract | BACKGROUND: Stroke is prevalent in hypertensive population. It has been suggested that monospecific unsaturated fatty acids (USFA) have potential effect on protection against stroke. However, the effect of saturated fatty acids (SFAs) on stroke is controversial. Therefore, we studied the relationship between recent stroke and serum levels of fatty acids including both USFAs and SFAs in hypertensive patients. METHODS: 89 pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient experiencing a stroke within 48 hours before examination and a hypertensive patient without stroke. 6 categories of serum fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated. Data were analyzed using R version 3.0.1. RESULTS: There were differences in educational level (P¼0.002) and occupation (P<0.001) between stroke and non-stroke participants. Non-stroke participants had higher levels of total cholesterol (P<0.001), triglyceride (P¼0.041), LDL (P¼0.048) and HDL (P¼0.001). All the 6 fatty acid levels were higher in non-stroke participants (P¼0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). Before adjustment, recent stroke was inversely associated with fatty acid levels except lignoceric acid’s. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with recent stroke. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR¼0.965, 95%CI¼0.942-0.990, P¼0.005), behenic acid (OR¼0.778, 95%CI¼0.664-0.939, P¼0.009), nervonic acid (OR¼0.323, 95%CI¼0.121-0.860, P¼0.024) with recent stroke were still highly significant. CONCLUSION: The levels of the fatty acids except lignoceric acid were inversely associated with recent stroke. Our results raise the possibility that both USFAs and SFAs may have beneficial effect on reduction of stroke risk in hypertensive population. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc.. The Journal's web site is located at http://www.ashjournal.com | - |
dc.relation.ispartof | American Society of Hypertension. Journal | - |
dc.subject | USFA | - |
dc.subject | SFA | - |
dc.subject | Stroke | - |
dc.subject | Hypertension | - |
dc.title | Investigating the relationship between stroke and serum fatty acids in hypertensive population | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Cheung, BMY: mycheung@hkucc.hku.hk | - |
dc.identifier.authority | Cheung, BMY=rp01321 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jash.2014.07.021 | - |
dc.identifier.hkuros | 254016 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | suppl 1 | - |
dc.identifier.spage | e9, abstract no. LB-P-07 | - |
dc.identifier.epage | e9, abstract no. LB-P-07 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1878-7436 | - |