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- Publisher Website: 10.1016/j.neubiorev.2015.07.015
- Scopus: eid_2-s2.0-84940045554
- PMID: 26363665
- WOS: WOS:000364271200002
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Article: Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons
Title | Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons |
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Authors | |
Keywords | Complement factors Cytokines Depression Neurohormones Neuroinflammation Prostaglandins Sickness response Systemic inflammation |
Issue Date | 2015 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev |
Citation | Neuroscience & Biobehavioral Reviews, 2015, v. 57, p. 30-45 How to Cite? |
Abstract | Systemic inflammation leads to a variety of physiological (e.g. fever) and behavioral (e.g. anorexia, immobility, social withdrawal, depressed mood, disturbed sleep) responses that are collectively known as sickness. While these phenomena have been studied for the past few decades, the neurobiological mechanisms by which sickness occurs remain unclear. In this review, we first revisit how the body senses and responds to infections and injuries by eliciting systemic inflammation. Next, we focus on how peripheral inflammatory molecules such as cytokines, prostaglandins, and activated complement factors communicate with the brain to trigger neuroinflammation and sickness. Since depression also involves inflammation, we further elaborate on the interrelationship between sickness and depression. Finally, we discuss how immune activation can modulate neurons in the brain, and suggest future perspectives to help unravel how changes in neuronal functions relate to sickness responses. |
Persistent Identifier | http://hdl.handle.net/10722/218630 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.810 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Poon, DCH | - |
dc.contributor.author | Ho, YS | - |
dc.contributor.author | Chiu, K | - |
dc.contributor.author | Wong, HL | - |
dc.contributor.author | Chang, RCC | - |
dc.date.accessioned | 2015-09-18T06:48:42Z | - |
dc.date.available | 2015-09-18T06:48:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Neuroscience & Biobehavioral Reviews, 2015, v. 57, p. 30-45 | - |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | http://hdl.handle.net/10722/218630 | - |
dc.description.abstract | Systemic inflammation leads to a variety of physiological (e.g. fever) and behavioral (e.g. anorexia, immobility, social withdrawal, depressed mood, disturbed sleep) responses that are collectively known as sickness. While these phenomena have been studied for the past few decades, the neurobiological mechanisms by which sickness occurs remain unclear. In this review, we first revisit how the body senses and responds to infections and injuries by eliciting systemic inflammation. Next, we focus on how peripheral inflammatory molecules such as cytokines, prostaglandins, and activated complement factors communicate with the brain to trigger neuroinflammation and sickness. Since depression also involves inflammation, we further elaborate on the interrelationship between sickness and depression. Finally, we discuss how immune activation can modulate neurons in the brain, and suggest future perspectives to help unravel how changes in neuronal functions relate to sickness responses. | - |
dc.language | eng | - |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev | - |
dc.relation.ispartof | Neuroscience & Biobehavioral Reviews | - |
dc.subject | Complement factors | - |
dc.subject | Cytokines | - |
dc.subject | Depression | - |
dc.subject | Neurohormones | - |
dc.subject | Neuroinflammation | - |
dc.subject | Prostaglandins | - |
dc.subject | Sickness response | - |
dc.subject | Systemic inflammation | - |
dc.title | Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons | - |
dc.type | Article | - |
dc.identifier.email | Chiu, K: datwai@hkucc.hku.hk | - |
dc.identifier.email | Chang, RCC: rccchang@hku.hk | - |
dc.identifier.authority | Chiu, K=rp01973 | - |
dc.identifier.authority | Chang, RCC=rp00470 | - |
dc.identifier.doi | 10.1016/j.neubiorev.2015.07.015 | - |
dc.identifier.pmid | 26363665 | - |
dc.identifier.scopus | eid_2-s2.0-84940045554 | - |
dc.identifier.hkuros | 251996 | - |
dc.identifier.hkuros | 276774 | - |
dc.identifier.volume | 57 | - |
dc.identifier.spage | 30 | - |
dc.identifier.epage | 45 | - |
dc.identifier.isi | WOS:000364271200002 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0149-7634 | - |