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Article: Hypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery

TitleHypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery
Authors
Keywordschitosan
drug delivery
drug release
hypromellose
polyelectrolyte complex
Issue Date2015
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2015, v. 7 n. 19, p. 10501-10510 How to Cite?
AbstractPolyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1–2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2–3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.
Persistent Identifierhttp://hdl.handle.net/10722/219124
ISSN
2023 Impact Factor: 8.3
2023 SCImago Journal Rankings: 2.058
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, WF-
dc.contributor.authorShum, HC-
dc.date.accessioned2015-09-18T07:13:47Z-
dc.date.available2015-09-18T07:13:47Z-
dc.date.issued2015-
dc.identifier.citationACS Applied Materials & Interfaces, 2015, v. 7 n. 19, p. 10501-10510-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/219124-
dc.description.abstractPolyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1–2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2–3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.subjectchitosan-
dc.subjectdrug delivery-
dc.subjectdrug release-
dc.subjecthypromellose-
dc.subjectpolyelectrolyte complex-
dc.titleHypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery-
dc.typeArticle-
dc.identifier.emailLai, WF: wflai@hku.hk-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.identifier.doi10.1021/acsami.5b01984-
dc.identifier.scopuseid_2-s2.0-84930227176-
dc.identifier.hkuros250690-
dc.identifier.volume7-
dc.identifier.issue19-
dc.identifier.spage10501-
dc.identifier.epage10510-
dc.identifier.isiWOS:000355055000049-
dc.publisher.placeUnited States-
dc.identifier.issnl1944-8244-

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