File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.expneurol.2008.07.015
- Scopus: eid_2-s2.0-53949098953
- PMID: 18762185
- WOS: WOS:000260617400016
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action
Title | Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action |
---|---|
Authors | |
Keywords | Deep brain stimulation Premature responding reaction time task Nucleus accumbens |
Issue Date | 2008 |
Citation | Experimental Neurology, 2008, v. 214, n. 1, p. 135-139 How to Cite? |
Abstract | The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity. Rats received bilateral stimulation at the level of the nucleus accumbens core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. Our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown Copyright © 2008. |
Persistent Identifier | http://hdl.handle.net/10722/219853 |
ISSN | 2021 Impact Factor: 5.620 2020 SCImago Journal Rankings: 1.779 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sesia, Thibaut | - |
dc.contributor.author | Temel, Yasin | - |
dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Blokland, Arjan | - |
dc.contributor.author | Steinbusch, Harry W M | - |
dc.contributor.author | Visser-Vandewalle, Veerle | - |
dc.date.accessioned | 2015-09-24T04:44:05Z | - |
dc.date.available | 2015-09-24T04:44:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Experimental Neurology, 2008, v. 214, n. 1, p. 135-139 | - |
dc.identifier.issn | 0014-4886 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219853 | - |
dc.description.abstract | The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity. Rats received bilateral stimulation at the level of the nucleus accumbens core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. Our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown Copyright © 2008. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental Neurology | - |
dc.subject | Deep brain stimulation | - |
dc.subject | Premature responding reaction time task | - |
dc.subject | Nucleus accumbens | - |
dc.title | Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.expneurol.2008.07.015 | - |
dc.identifier.pmid | 18762185 | - |
dc.identifier.scopus | eid_2-s2.0-53949098953 | - |
dc.identifier.volume | 214 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 135 | - |
dc.identifier.epage | 139 | - |
dc.identifier.eissn | 1090-2430 | - |
dc.identifier.isi | WOS:000260617400016 | - |
dc.identifier.issnl | 0014-4886 | - |