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- Publisher Website: 10.1016/j.expneurol.2010.08.035
- Scopus: eid_2-s2.0-77958493029
- PMID: 20837005
- WOS: WOS:000283835800005
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Article: Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
Title | Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray |
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Authors | |
Keywords | Agoraphobia Electrical stimulation Panic disorder Anticipatory anxiety Periaqueductal gray |
Issue Date | 2010 |
Citation | Experimental Neurology, 2010, v. 226, n. 2, p. 293-300 How to Cite? |
Abstract | Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12. h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12. h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12. h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. © 2010 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/219865 |
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.552 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Blokland, Arjan | - |
dc.contributor.author | Tan, Sonny | - |
dc.contributor.author | Vlamings, Rinske | - |
dc.contributor.author | Sesia, Thibaut | - |
dc.contributor.author | Aziz-Mohammadi, Mujzgan | - |
dc.contributor.author | Visser-Vandewalle, Veerle | - |
dc.contributor.author | Steinbusch, Harry W M | - |
dc.contributor.author | Schruers, Koen | - |
dc.contributor.author | Temel, Yasin | - |
dc.date.accessioned | 2015-09-24T04:44:10Z | - |
dc.date.available | 2015-09-24T04:44:10Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Experimental Neurology, 2010, v. 226, n. 2, p. 293-300 | - |
dc.identifier.issn | 0014-4886 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219865 | - |
dc.description.abstract | Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12. h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12. h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12. h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. © 2010 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental Neurology | - |
dc.subject | Agoraphobia | - |
dc.subject | Electrical stimulation | - |
dc.subject | Panic disorder | - |
dc.subject | Anticipatory anxiety | - |
dc.subject | Periaqueductal gray | - |
dc.title | Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.expneurol.2010.08.035 | - |
dc.identifier.pmid | 20837005 | - |
dc.identifier.scopus | eid_2-s2.0-77958493029 | - |
dc.identifier.volume | 226 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 293 | - |
dc.identifier.epage | 300 | - |
dc.identifier.eissn | 1090-2430 | - |
dc.identifier.isi | WOS:000283835800005 | - |
dc.identifier.issnl | 0014-4886 | - |