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- Publisher Website: 10.1016/j.bbr.2011.09.041
- Scopus: eid_2-s2.0-81355148484
- PMID: 22001615
- WOS: WOS:000298774600011
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Article: Motor and non-motor behaviour in experimental Huntington's disease
Title | Motor and non-motor behaviour in experimental Huntington's disease |
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Authors | |
Keywords | Transgenic rats Motivation Huntington's disease Hypermobility Anxiety Food intake Hedonia |
Issue Date | 2012 |
Citation | Behavioural Brain Research, 2012, v. 226, n. 2, p. 435-439 How to Cite? |
Abstract | In this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor and non-motor features (anxiety, motivation and hedonia) of disease over time and their interactions. We found tgHD animals to be hyperkinetic in the open field test compared to their wild-type littermates at all ages tested, which was accompanied by reduced anxiety-like behaviour in the open field test and the elevated zero maze, but not in the home cage emergence test. No major changes were found in hedonia (sucrose intake test) and motivation for food (food intake test). Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease. © 2011 Elsevier B.V. |
Persistent Identifier | http://hdl.handle.net/10722/219875 |
ISSN | 2021 Impact Factor: 3.352 2020 SCImago Journal Rankings: 1.113 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zeef, Dagmar H. | - |
dc.contributor.author | Vlamings, Rinske | - |
dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Tan, Sonny | - |
dc.contributor.author | Janssen, Marcus L F | - |
dc.contributor.author | Jahanshahi, Ali | - |
dc.contributor.author | Hoogland, Govert | - |
dc.contributor.author | Prickaerts, Jos | - |
dc.contributor.author | Steinbusch, Harry W M | - |
dc.contributor.author | Temel, Yasin | - |
dc.date.accessioned | 2015-09-24T04:44:13Z | - |
dc.date.available | 2015-09-24T04:44:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Behavioural Brain Research, 2012, v. 226, n. 2, p. 435-439 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219875 | - |
dc.description.abstract | In this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor and non-motor features (anxiety, motivation and hedonia) of disease over time and their interactions. We found tgHD animals to be hyperkinetic in the open field test compared to their wild-type littermates at all ages tested, which was accompanied by reduced anxiety-like behaviour in the open field test and the elevated zero maze, but not in the home cage emergence test. No major changes were found in hedonia (sucrose intake test) and motivation for food (food intake test). Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease. © 2011 Elsevier B.V. | - |
dc.language | eng | - |
dc.relation.ispartof | Behavioural Brain Research | - |
dc.subject | Transgenic rats | - |
dc.subject | Motivation | - |
dc.subject | Huntington's disease | - |
dc.subject | Hypermobility | - |
dc.subject | Anxiety | - |
dc.subject | Food intake | - |
dc.subject | Hedonia | - |
dc.title | Motor and non-motor behaviour in experimental Huntington's disease | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bbr.2011.09.041 | - |
dc.identifier.pmid | 22001615 | - |
dc.identifier.scopus | eid_2-s2.0-81355148484 | - |
dc.identifier.volume | 226 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 435 | - |
dc.identifier.epage | 439 | - |
dc.identifier.eissn | 1872-7549 | - |
dc.identifier.isi | WOS:000298774600011 | - |
dc.identifier.issnl | 0166-4328 | - |