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Conference Paper: Small-molecule suppressors of proteoglycan catabolism in degenerative disc cells
Title | Small-molecule suppressors of proteoglycan catabolism in degenerative disc cells |
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Authors | |
Issue Date | 2015 |
Citation | The 61st Annual Meeting of the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015. How to Cite? |
Abstract | INTRODUCTION: Proteoglycans (PGs) occupy the predominant extracellular matrix (ECM) components in cartilages and intervertebral discs (IVDs). Large numbers of compositional glycosaminoglycans (GAGs) render PG highly hydrophilic for providing water retention capacity and swelling pressure to the connective tissues to neutralize the axial mechanical loads [1]. Its loss of content is tightly associated with the tissue degeneration. In the intervertebral disc degeneration (IDD), a reduction of PGs in central gelatinous nucleus pulposus (NP) was characterized as the first event, which consequently leads to a replacement of fibrocartilaginous ... |
Persistent Identifier | http://hdl.handle.net/10722/220258 |
DC Field | Value | Language |
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dc.contributor.author | Sun, Y | - |
dc.contributor.author | Masuda, K | - |
dc.contributor.author | Chan, D | - |
dc.contributor.author | Cheung, K | - |
dc.contributor.author | Leung, V | - |
dc.date.accessioned | 2015-10-16T06:34:03Z | - |
dc.date.available | 2015-10-16T06:34:03Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 61st Annual Meeting of the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015. | - |
dc.identifier.uri | http://hdl.handle.net/10722/220258 | - |
dc.description.abstract | INTRODUCTION: Proteoglycans (PGs) occupy the predominant extracellular matrix (ECM) components in cartilages and intervertebral discs (IVDs). Large numbers of compositional glycosaminoglycans (GAGs) render PG highly hydrophilic for providing water retention capacity and swelling pressure to the connective tissues to neutralize the axial mechanical loads [1]. Its loss of content is tightly associated with the tissue degeneration. In the intervertebral disc degeneration (IDD), a reduction of PGs in central gelatinous nucleus pulposus (NP) was characterized as the first event, which consequently leads to a replacement of fibrocartilaginous ... | - |
dc.language | eng | - |
dc.relation.ispartof | Annual Meeting of Orthopaedic Research Society, ORS 2015 | - |
dc.title | Small-molecule suppressors of proteoglycan catabolism in degenerative disc cells | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, D: chand@hku.hk | - |
dc.identifier.email | Cheung, K: cheungmc@hku.hk | - |
dc.identifier.email | Leung, V: vicleung@hku.hk | - |
dc.identifier.authority | Chan, D=rp00540 | - |
dc.identifier.authority | Cheung, K=rp00387 | - |
dc.identifier.authority | Leung, V=rp01764 | - |
dc.description.nature | postprint | - |
dc.identifier.hkuros | 256068 | - |