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Conference Paper: Assessing iron load in deep grey matter brain nuclei of Parkinson's Disease with L2-regularized quantitative susceptibility mapping

TitleAssessing iron load in deep grey matter brain nuclei of Parkinson's Disease with L2-regularized quantitative susceptibility mapping
Authors
Li, DTHHui, ESKChan, QChua, SEMcAlonan, GHo, SLMak, HKF
Issue Date2015
Citation
The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015. How to Cite?
AbstractDegeneration of dopaminergic neuron is one of the major clinical characteristics of Parkinson’s disease (PD). Abnormal iron deposition in the mid-brain nuclei was postulated to be the cause of neurodegeneration. In this study, we employed quantitative susceptibility mapping (QSM) as a tool to examine iron content of different brain nuclei. Iron concentrations in terms of magnetic susceptibility of the 6 brain nuclei were presented. ROI analysis revealed high iron concentration in substantia nigra of PD patients which confirmed the clinical findings. This study also demonstrated QSM as a potential tool for evaluation of in vivo iron metabolism in neurodegenerative disease.
DescriptionElectronic Poster Session: Neuro B - Mechanisms of Neural Degeneration & Damage 1: no. 4278
Persistent Identifierhttp://hdl.handle.net/10722/220289

 

DC FieldValueLanguage
dc.contributor.authorLi, DTH-
dc.contributor.authorHui, ESK-
dc.contributor.authorChan, Q-
dc.contributor.authorChua, SE-
dc.contributor.authorMcAlonan, G-
dc.contributor.authorHo, SL-
dc.contributor.authorMak, HKF-
dc.date.accessioned2015-10-16T06:35:10Z-
dc.date.available2015-10-16T06:35:10Z-
dc.date.issued2015-
dc.identifier.citationThe 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015.-
dc.identifier.urihttp://hdl.handle.net/10722/220289-
dc.descriptionElectronic Poster Session: Neuro B - Mechanisms of Neural Degeneration & Damage 1: no. 4278-
dc.description.abstractDegeneration of dopaminergic neuron is one of the major clinical characteristics of Parkinson’s disease (PD). Abnormal iron deposition in the mid-brain nuclei was postulated to be the cause of neurodegeneration. In this study, we employed quantitative susceptibility mapping (QSM) as a tool to examine iron content of different brain nuclei. Iron concentrations in terms of magnetic susceptibility of the 6 brain nuclei were presented. ROI analysis revealed high iron concentration in substantia nigra of PD patients which confirmed the clinical findings. This study also demonstrated QSM as a potential tool for evaluation of in vivo iron metabolism in neurodegenerative disease.-
dc.languageeng-
dc.relation.ispartofISMRM / SMRT 2015-
dc.titleAssessing iron load in deep grey matter brain nuclei of Parkinson's Disease with L2-regularized quantitative susceptibility mapping-
dc.typeConference_Paper-
dc.identifier.emailHui, ESK: edshui@hku.hk-
dc.identifier.emailChua, SE: sechua@hkucc.hku.hk-
dc.identifier.emailMcAlonan, G: mcalonan@hkucc.hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk-
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hk-
dc.identifier.authorityHui, ESK=rp01832-
dc.identifier.authorityChua, SE=rp00438-
dc.identifier.authorityMcAlonan, G=rp00475-
dc.identifier.authorityHo, SL=rp00240-
dc.identifier.authorityMak, HKF=rp00533-
dc.identifier.hkuros255760-

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