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- Scopus: eid_2-s2.0-0022764235
- PMID: 2429475
- WOS: WOS:A1986D727500003
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Article: Maldevelopment Of Spinal Cord--Substance P In Spina Bifida.
Title | Maldevelopment Of Spinal Cord--Substance P In Spina Bifida. |
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Authors | |
Issue Date | 1986 |
Citation | Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhood, 1986, v. 41 n. 4, p. 206-208 How to Cite? |
Abstract | Recent Works Have Shown That The Neuropeptide, Substance P, Is An Important Element Of The Central Nervous System, Functioning As A Neurotransmitter As Well As Moderating Neural Development. In A Previous Communication, We Provided Indirect Evidence That Substance P Played A Role In The Pathogenesis And Pathophysiology Of Spina Bifida By Showing An Elevation Of Csf Substance P Concentrations In Affected Foetuses And Babies. In This Study, We Investigated Directly The Occurrence Of Substance P In Spinal Cord Tissues In Spina Bifida And Compared It To That Found During Normal Development. Using Radioimmunoassay, Concentrations Of Substance P Were Measured In The Spinal Cords Of 20 Normal Human Foetuses (Aged 9-21 Weeks) And 4 Foetuses With Spina Bifida (Aged 17-19 Weeks). Substance P Was Detected In Substantial Amounts In The Normal Foetal Spinal Cord As Early As 9 Weeks' Gestation, And There Was Progressive Accumulation With Age: Mean Concentrations +/- S.E.M. In 3 Subgroups Were 56.3 +/- 4.9 Pmol G-1 (9-12 Weeks), 59.5 +/- 7.2 Pmol G-1 (13-16 Weeks) And 117.3 +/- 7.2 Pmol G-1 (17-21 Weeks). In Spina Bifida, Substance P Was Severely Depleted In The Dysraphic Segment Of The Cord (Mean Concentration +/- S.E.M. = 22.1 +/- 2.3 Pmol G-1) And Moderately So In The Segment Above The Dysraphism (Mean Concentration +/- S.E.M. = 47.2 +/- 4.2 Pmol G-1).(Abstract Truncated At 250 Words) |
Persistent Identifier | http://hdl.handle.net/10722/220831 |
ISSN | 2019 SCImago Journal Rankings: 0.125 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tam, PKH | en_US |
dc.contributor.author | Lister, J | en_US |
dc.date.accessioned | 2015-10-19T07:18:55Z | - |
dc.date.available | 2015-10-19T07:18:55Z | - |
dc.date.issued | 1986 | - |
dc.identifier.citation | Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhood, 1986, v. 41 n. 4, p. 206-208 | en_US |
dc.identifier.issn | 0174-3082 | - |
dc.identifier.uri | http://hdl.handle.net/10722/220831 | - |
dc.description.abstract | Recent Works Have Shown That The Neuropeptide, Substance P, Is An Important Element Of The Central Nervous System, Functioning As A Neurotransmitter As Well As Moderating Neural Development. In A Previous Communication, We Provided Indirect Evidence That Substance P Played A Role In The Pathogenesis And Pathophysiology Of Spina Bifida By Showing An Elevation Of Csf Substance P Concentrations In Affected Foetuses And Babies. In This Study, We Investigated Directly The Occurrence Of Substance P In Spinal Cord Tissues In Spina Bifida And Compared It To That Found During Normal Development. Using Radioimmunoassay, Concentrations Of Substance P Were Measured In The Spinal Cords Of 20 Normal Human Foetuses (Aged 9-21 Weeks) And 4 Foetuses With Spina Bifida (Aged 17-19 Weeks). Substance P Was Detected In Substantial Amounts In The Normal Foetal Spinal Cord As Early As 9 Weeks' Gestation, And There Was Progressive Accumulation With Age: Mean Concentrations +/- S.E.M. In 3 Subgroups Were 56.3 +/- 4.9 Pmol G-1 (9-12 Weeks), 59.5 +/- 7.2 Pmol G-1 (13-16 Weeks) And 117.3 +/- 7.2 Pmol G-1 (17-21 Weeks). In Spina Bifida, Substance P Was Severely Depleted In The Dysraphic Segment Of The Cord (Mean Concentration +/- S.E.M. = 22.1 +/- 2.3 Pmol G-1) And Moderately So In The Segment Above The Dysraphism (Mean Concentration +/- S.E.M. = 47.2 +/- 4.2 Pmol G-1).(Abstract Truncated At 250 Words) | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhood | en_US |
dc.title | Maldevelopment Of Spinal Cord--Substance P In Spina Bifida. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tam, PKH:paultam@hkucc.hku.hk | - |
dc.identifier.authority | Tam, PKH=rp00060 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 2429475 | - |
dc.identifier.scopus | eid_2-s2.0-0022764235 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 206 | - |
dc.identifier.epage | 208 | - |
dc.identifier.isi | WOS:A1986D727500003 | - |
dc.identifier.issnl | 0174-3082 | - |